OKTADIN (Octadinum) b - (N-Azatsiklooktil) - etilguanidina sulfate.

     Synonyms : Abapressin, Izobarin, Ismelin, Sanotenzin, Abapressin, Antipres, Azetidin, Declidin, Eutensol, Guanethidini sulfas, Guanexil, Guanisol, Ipoctal, Ipoguanin, Iporal, Ismelin, Isobarin, Octatenzine, Oftalmotonil, Oktatensin, Pressedin, Sanotensin, Visutensil et al .

     The white crystalline powder bitter taste. Little is soluble in water.

     Simpatoliticheskoe of oktadina because it selectively accumulate in the granules sympathetic nerve endings and replaces one-Levophed adrenergichesky mediator. Part released a mediator to postsinapticheskih-adrenoreceptor pressornoe and provides short-term effects, but most of the mediator has been destroyed by aksonalnoy monoaminoksidazy. As a result of depletion in noradrenalina adrenergic after being reduced or terminated transmission of neural excitation.

     Violation of neural excitation involves, in addition, that the accumulating in nerve end, oktadin provides them mestnoanesteziruyuschee effect. At the cardiovascular system oktadin affect dvuhfazno : first developed transitory pressornaya reaction from heart palpitations and increased emissions, and then comes the progressive lowering of systolic and diastolic AD, decreasing the frequency of heart, minute volume and pulse pressure, and later (after 2-day 3 when administered orally) is resistant hypotension. Pressornaya initial reaction may last up to several hours. With long-term use of anti-hypertensive drugs may decrease because of the gradual increase in cardiac ejection.

     Applied oktadin as antihypertensive funds. The drug has a strong anti-hypertensive effect, and with the right selection of doses may cause a reduction in patients with AD patients in different stages, including severe and persistent high pressure.

     Oktadin effective when administered. Absorbed slowly. Anti-hypertensive effect in hypertensive disease develops slowly; He begins to emerge after 2 - 3 days after receiving the drug reaches a maximum at 7 - 8-day treatment, and after receiving prodazhaetsya another 4-14 days. The drug causes heart ischemia, a decrease venous pressure, and in some cases, peripheral resistance. Early treatment may reduce the filtering functions of the kidney and renal blood flow, but further treatment and permanent AD lower levels were (N. A. Ratner, etc.).

     To treat hypertension oktadin appointed interior in the form of tablets. Doses should be collected individually depending on the stage of disease, the general condition of the patient, portable products, etc. beginning with a small dose of 0,01 - - 0.0125 g (10 - 12, 5 mg), 1 per day, and then the dosage gradually increase (usually weekly on October 12, 5 mg) to 0.05 - 0,075 grams per day. Usually enough smaller doses : in severe cases, up to 60 mg a day, more light-10-30 mg. The daily dose can be taken in one admission (morning). After selecting a therapeutic effect individually supporting dose. Treatment for long.

     Treatment oktadinom start preferably in a hospital. In a clinical drug should be used with caution, with constant medical supervision. There is a need to consider individual variation in sensitivity to patients oktadinu.

     Patients Elder preparation designate smaller doses, starting with 6, 25 mg (1 / 4 tablets) one time a day, then gradually increasing the dose of 6, 25 mg daily dose of 25 to 50 mg.

     In applying oktadina may be side effects : dizziness, weakness, adinamiya, nausea, vomiting, swelling of the mucous membrane nose, pain in the gland tumors, diarrhea (due to increased peristalsis of the bowel because of the suppression of the sympathetic innervation), the delay fluid fabrics. There may increase daily fluctuations AD. Anti-hypertensive effect of the drug is often accompanied by the development Orthostatic Hypotension in some cases can Orthostatic collapse (especially in the first few weeks of treatment). To prevent collapse, patients must within 1, 5, 2 h after administration of the drug in a horizontal position and slowly move out of lying in standing; In some cases, the dosage should be reduced.

     Before the new antigipertenzivnyh funds (Hydrochloride, b-adrenoblokatory etc.) oktadin was one of the main drugs for the treatment of hypertension. But now he has not lost its significance and used, especially under severe form of hypertension. The drug has long. Adverse events can be reduced to podorav doses. Diarrhea can facilitate the reception holinoliticheskih drugs. Oktadin may be nominated along with other hypotensive means (Reserpine, apressin, Diuretics); The simultaneous use of anti-hypertensive effect diuretikami increases, and warns the delay fluid in the tissues. When combined use with other drugs oktadina reduce the dose.

     P ONTRA : sharply pronounced atherosclerosis, acute violations of cerebral circulation, myocardial infarction, hypotension, expressed lack of kidney function. Do not assign oktadin with feohromotsitome since the beginning of the drug could raise AD. There should be appointed oktadin conjunction with tricyclic antidepressants : aminazinom, ephedrine. Patients who are receiving MAO inhibitors (see), it should be before the oktadina make a break of two weeks. Patients due surgery should discontinue use of the drug several days before the operation.

     In ophthalmic practice oktadin sometimes used for backfilling in konyunktivalny bag (1 to 2 drops of 5% solution of 1 to 2 times a day) with primary open - glaucoma. The drug is moderate excessive facilitates aqueous outflow of moisture, reduces its products and reduces inner pressure. Unlike holinomimeticheskih substances (pilocarpine, etc.) oktadin not affect the accommodation; Less serious breach of patients and the ability to see in low light. Patients who are closed and narrow chamber angle, oktadin not apply, because there may be a greater oftalmotonusa. In acute glaucoma drug is not shown.

     Method of issuance : powder; Pills to 0,025 g (25 mg).

     Storage : List B. In dry, the dark spot.

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