ESTRON (Oestronum). 3-Oksi- estra-1, 3, 5 (10) trien-17- it.

     Synonyms: Follikulin, Cristallovar, Estrone, Estronum, Estrugenone, Estrusol, Folestrin, Folliculinum, Femidin, Glandubolin, Gynoestryl, Ketodestrin, Ketohydroxyestrin, Menformon, Oestrobin, Oestroglandol, Oestrogynon, Progynon, Theelin, Thelestrin, Thelykinin and others.

     The white crystalline substance. Almost nerastvorim in water, soluble in alcohol, broadcast, oils.

     Estrone Acne is a natural hormone, necessary for the normal development of the female body. He is being produced by the ovaries in the period with the onset of sexual maturity and accrue maturing follikulah before menopausal period.

     But hormone yellow body Acne hormone involved in the menstrual cycle: two hormones necessary for the function of reproduction.

     In the body are women, and others close to estronu on the structure and action of hormones, including vysokoaktivny Acne hormone estradiol. These hormones called estrogen, or oestrogenic substances, the fact that they are from castrate animals Samok lewdness (cycle).

     At present the data in the body there are specialized estrogen receptors, which are interacting with, estrogens have a specific impact on the relevant authorities (bodies target).

     For medical purposes Estrone (follikulin) from the urine of pregnant women or pregnant animals. During pregnancy a hormone Unit has been improved and it made large quantities of urine.

     With the drug, the body has a specific effect inherent oestrogenic products: cause endometrial proliferation, stimulated the development of the uterus and female secondary sexual characteristics in their underdevelopment, reduces and eliminates common disorders encountered in the body of women on the grounds of insufficient sex gland function in menopausal period or after gynecological operations.

     Activity estrona biological method to determine its ability to cause lewdness castrate samok (mice or rats). At 1 mg contains 10000 ED.

     Estrone, like other estrogenic drugs used in pathological conditions associated with impaired function of the ovaries: in primary and secondary amenorrhea, secondary sexual inadequacy, gipoplazii sexual apparatus and secondary sexual characteristics, as climacteric or postkastratsionnyh disorders, infertility, weakness generic activities , perenoshennoy pregnancy, etc. There is also used in the treatment of hypertensive disease in menopausal period, and sometimes with peripheral vascular cramps.

     Estrogen has gipoholesterinemicheskoe effect, reduce the rate of cholesterol / Phospholipid, increase content in a blood-lipoproteidov. Their use for the treatment and prevention of atherosclerosis is difficult because of a long application men have feminization phenomenon, but women may proliferativnye changes in the endometrial and uterine bleeding.

     Enter Estrone intramuscularly in the form of oil production.

     For injection drug produced entitled <<solution follikulina in oil injection> (Solutio Folliculini oleosa pro injectionibus) in the ampoule and 1 ml 0.05% and 0.1% solution. The solution is oily liquid light-yellow; 1 ml of 0.05% or 0.1% solution with 5000 or 10000 ED.

     Follikulin enter with primary amenorrhea with underdevelopment genital organs and secondary sexual characteristics of 10000-20000 ED daily or every other day for 1 to 2 months and a significant increase in the uterus before; Since then appoint progesterone intramuscularly to 5 mg daily for 6 - 8 days. If necessary to repeat courses therapy. In secondary amenorrhea impose on 10000 ED daily for 15 to 16 days, followed by the appointment of progesterone or pregnina within 6 to 8 days. If no stable effect, treatment repeat.

     When sensing and oligomenoree, algodismenoree, infertility due to hypopituitatism ovarian and uterine underdevelopment appoint Estrone after menstruation; Enter daily to 5000 ED-10000 for 15 to 16 days and then if there is evidence appoint progesterone or pregnin over 6 - 8 days.

     The course of treatment can be repeated several times at the same time after menstruation.

     In sharp gipoplazii degree sexual apparatus and the need for long-term estrogen therapy more convenient to use drugs prolongirovennogo action (see Estradiola dipropionate).

     The pathological phenomena associated with the menopausal period and with the surgical removal of the ovaries (angionevroticheskie phenomenon, depression, etc.) require the introduction of 5000-10000 ED day or one-day courses on Feb. 10 - 15 injection. With the resumption of symptoms similar treatment. Doses must, however, the strictly tailored depending on the phase of menopausal period vyrazhennosti cardiovascular and nervous disorders; To identify the minimum effective dosage.

     With weak and generic perenoshennoy pregnancy appoint Estrone before imposing rodouskoryayuschih funds (for 2 to 3 hours). Enter intramuscularly 40000 50000 - ED.

     Now instead estrona a solution for injection follikulina increasingly applying synthetic estrogenic drugs (norethisterone, etc.).

     Estrone and other estrogenic drugs combination women with malignant and benign tumors of the reproductive organs, milk glands and other organs (under age 60) with mastopatii, endometrite, bleeding propensity for breeding, as well as in giperestrogennoy phase menopausal period.

     Too long follikulina use of oestrogen and other drugs can lead to uterine bleeding.

     Treatment should be under close medical supervision.

     Storage: in a cool, sheltered from the world scene.

     Rp. : Sol. Folliculini oleosae 0,05% 1 ml

     D.t.d. N. in ampull 6.

     S. At 1 1 ml intramuscularly once a day

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