OLANZAPIN (Olanzapine).

     Metil-4- 2 - (4-methyl piperazinil) -10 H tieno- [2,3-in] [1,5] benzodiazepine.

     Synonym : Zipreksa, Zypre ? a.

     The structure and action close to klozapinu (azaleptinu). Is that in benzodiazepinovom kernel contains methyl tienilnuyu phenyl group instead.

     Has expressed antipsihoticheskoe effect.

     Lock central dofamine and serotonin receptors.

     Quickly and completely absorbed in the digestive tract, Cma x 6 h; T1 / 2-hour 29-55; Being biotransformation kidneys.

     Applied with acute schizophrenia and other psychoses, accompanied by positive (delirium, hallucinations, thought disorder, hostility, etc.) or negative (dull passion, emotional and social otgorozhennost, poverty voice, etc.) symptoms. Decreases cognitive and behavioral violations.

     Can be used as a means protivorvotnogo.

     Assign inside (regardless of time and meals) from the 0,005-0,01 g doses (5-10 mg) a day (one), with a gradual increase to its 0,015-0,02 g (15-20 mg) a day.

     Possible side effects : drowsiness, extrapiramidale disorders, dizziness, Orthostatic Hypotension, holestaticheskaya jaundice, dry mouth, constipation, appetite increase, peripheral oedema; The increase in the level of prolactin and transaminaz liver.

     In violation of the liver, epilepsy, mielosupressii, isolationist prostate gland, paralytic ileuse, children up to 18 years appoint drug is not recommended.

     With caution should be used with Parkinson's disease, diabetes, while receiving drugs udlinyayuschih interval Q-T (especially older).

     Compounding the effects of alcohol and impaired - levodopa.

     Product : pills to 0,005; 0.0075 and 0.01 g (5; 7.5 and 10 mg) (N.28).

     Storage : List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines