OLEANDOMITSINA phosphate (Oleandomycini phosphas).

     Oleandomitsin an antibiotic, produced radiant fungus Streptomyces antibioticus or other relevant microorganisms.

     Refers to a group of Antibiotic macrolides. In oleandomitsina molecules are aminosahar dezozamin and neutral sugar L-oleandroza associated with glyukozidno laktonom - oleandolidom.

     Synonyms : Amimycin, Cyclamycin, Matrimycin, Matromycin, Oleandocyn, Oleandomycin, Oleandomycinum phosphoricum, Romicil, Romycil and others.

     The crystalline powder or porous mass of white or white with a yellowish sheen color, bitter taste. The easily soluble in water, soluble in diluted solutions of acids, well soluble in alcohol. Gigroskopichen.

     Oleandomitsina phosphate activity is expressed in units of (ED). At 1 mg product contains at least 750 ED; 1 ED activity is 1 µ g oleandomitsina grounds.

     Oleandomitsin suppresses the growth and development of gram (staphylococci, streptococci, pnevmokokki, wand diphtheria, etc.) and some gram (gonokokki, meningokokki etc.) bacteria, and viruses rikketsy and large. Maloaktiven against intestinal bacillus and other gram coliform bacteria. Active against stafilikokkov resistant to penicillin and other antibiotics. Sometimes acting on pathogens resistant to erythromycin. In therapeutic doses are bakteriostaticheski.

     Oleandomitsin well absorbed when administered quickly spread into many organs and body fluids. After intact blood-brain barrier is not.

     Oleandomiditsa phosphate applied for the treatment of pneumonia, plevritov, abscesses lung, pleura empiem, bronhoektazy, tonzillitov, otites, protracted endocarditis, meningitis, sepsis (sepsis, and streptococcal pnevmokokkovogo) osteomyelitides abrasions, gonorrhea, enterocolitis, urinary tract infections and biliary tract (if not impressed parenhima liver) and other diseases caused by microorganisms, sensitive to the antibiotic resistant to other antibiotics.

     Because of that, in treating oleandomitsinom microflora, especially staphylococci may quickly become resistant to it, it is often combined with other antibiotics, especially tetracycline (see Oletetrin).

     Assign inside after eating.

     The average single dose for adults 0,25 g (ED 250000). Is every 4 to 6 hours

     Higher doses for adults : single 0.5 g daily 2 grams of higher daily doses for children : up to 3 years - 0.02 g / kg (20 mg = 20000 ED), from 3 to 6 years - 0.25 - 0.5 g (250000 - 500000 ED), from 6 to 14 years - 0.5-1, O g over 14-1, 0, 1, 5 g. Sutochnuyu dose divided into 4-6 receptions.

     The total dose and duration of treatment depends on the nature of disease and the effectiveness and acceptability of the drug. Following the acute symptoms of the disease, continue to apply the product in the next 48 hours. The average duration of treatment 5 to 7 days.

     Oleandomitsina phosphate is usually well. In some cases, there is nausea, vomiting, diarrhea. Possible allergic reactions : skin itch, urticaria, angionevrotichesky swelling. When complications reduced dose designate protivogistaminnye drugs; In persistent cases of drug overturned.

     The drug is not suitable for high individual chuvsvitelnosti, defeat parenhimy liver.

     Method of production : tablets, coated yellow to 0,125 grams (125000 ED) in a package of 10; 25; 40 and 100 pieces.

     Storage : List B. In dry place at room temperature.

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