OLETETRIN (Oletetrinum).

     Oletetrin a combined drug, consisting of a mixture of one part oleandomitsina phosphate and two parts tetracycline.

     In one pill (0,125 or 0.25 grams) oletetrina contained 41, 83 or 5 mg oleandomitsina and 83, 5 or 167 mg of tetracycline.

     In one capsule (0.25 g) contains 83 mg and 167 mg oleandomitsina tetracycline.

     In oletetrine combined antimicrobial properties oleandomitsina and broad-spectrum antibiotic tetracycline. When ingestion oletetrin absorbed and enters into many organs and body fluids. Effective against gram (staphylococci, streptococci, pnevmokokki, wand diphtheria, etc.) and gram (gonokokki, meningokokki, wand dysentery, Escherichia coli, etc.) microbial rikketsy, spirohet, major viruses; No effect on the smaller viruses and fungi, micobacterium tuberculosis. Resistance to drugs has been slower than some of its components.

     Assign oletetrin with varying etiology of pneumonia, severe bronchitis, angina, sinusitis, bronchitis middle ear, brucellosis, tularemia, some rikketsiozah, cholecystitis, pancreatitis, peritonitis, abrasions, carbuncles, osteomyelitis, inflammatory gynecological and urological diseases, gonorrhea and other infectious diseases.

     The drug can be used to prevent postoperative infectious complications.

     Assign inwards in the form of tablets or capsules.

     Under the dose for adults 0,25 g (ED 250000), daily 1 0 1 5 grams (1000000, 1500000 ED). The highest daily intake for adults 2 g (2000000 ED).

     Daily dose of a drug for children weighing 10 kg of 0,025 g / kg (25 mg / kg), 10 to 15 kg, 250 mg, 15 to 20 kg, 375 mg, 20 to 30 kg-500 mg, 30 to 40 kg, 725 mg. When body weight 40-50 kg appoint 1 g per day.

     Daily doses are equal parts 4-6 times a day (30 minutes before meals). The course of treatment depending on the nature and course of the disease five to 14 days or more. If necessary, repeat the treatment.

     Method of production : tablets, coated in 0,125 and 0,25 g (125000 - 250000 ED); Capsules of 0.25 g pack of 10 capsules.

     Storage : List B. In dry, the dark place at room temperature.

     Tetraolean (Tetraolean). Produced in Bulgaria drug tetraolean similar in composition and oletetrinu with drug sigmamitsin (Sigmamycin).

     Available in the form of capsules to 0.25 g (83 mg oleandomitsina phosphate or triatsetiloleandomitsina and 167 mg of tetracycline hydrochloride), and in vials for intramuscular introduction of 0,1 g of the drug (33, 3 mg oleandomitsina phosphate and 66, 7 mg of tetracycline hydrochloride), intravenous-to 0.25 and 0.5 g of the drug (83 mg or 167 oleandomitsina phosphate and 167 or 333 mg of tetracycline hydrochloride).

     Indications for use and contraindications are the same as for oletetrina.

     Assign an adult on the inside 1 0 1 5 grams a day, while heavy able to 2 g / day (4 reception from 6-hour intervals). The duration of treatment 5 to 7 days, rarely up to 14 days.

     Children designate in the following daily doses : birth weight of 10 kg 0,125 g, 10 to 15 kg, 0.25 g, 20 to 30 kg, 0.5 g, 30 to 40 g kg-0,725 , from 40 to 50 kg-1 year

     Intramuscularly and intravenously injecting just the acutely ill and not receiving the drug inside.

     As soon as possible, take drugs inside.

     For intramuscular dissolve the contents of a bottle in 2 ml of sterile water for injection or isotonic sodium chloride solution.

     Enter adult for the 0.2 - 0.3 g / day for 2 - 3 admission (to 0.1 g) at intervals of eight to 12 hours Children are 10 to 20 mg / kg / day in 2 admission (within 12 hours). A cord is not allowed.

     For intravenous injection using 1% solution; Dissolve 0.25, or 0.5 grams of the drug in 25 or 50 ml of sterile water for injection. Enter slowly (no more than 2 ml / min).

     It introduces the drip method (no more than 60 drops per minute) 0.1% solution, prepared to sterile water for injection, 5% glucose solution and isotonic sodium chloride solution.

     Solutions are ex tempore; Store in the refrigerator may be no more than 24 hours

     Average daily dose of intravenous drug for adults 1 g (2 admission to 500 mg every 12 h). The maximum daily intake for adults 2 g (4 of 500 mg intervals 6 h). Children are 15 to 25 mg / kg / day (2 - 4 at intervals of 12 or 6 h).

     Intravenous introduction to be made with caution.

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