OKSATSILLINA NATRIEVAYA SOL (Oxacillinum-natrium).

     Sodium salt 3-methyl fenil-5- izoksazolil- penicillin Monohydrate.

     Synonyms : Bristopen, Cryptocillin, Micropenin, Oxacillinum natricum, Oxazocilline, Penstaphocid, Prostaphlin, Resistopen, Stapenor and others.

     The white crystalline powder bitter to the taste. The easily soluble in water, it is difficult to alcohol. Resistant to slightly Wednesday.

     Oxacillin a semisynthetic penicillin. In his 6-molecule aminopenitsillanovaya acid balance atsilirovana 5-methyl fenilizoksazo-4- carboxylic acid.

     The spectrum antibacterial action oxacillin similar range benzylpenicillin.

     Oxacillin main feature is its effectiveness against strains of microorganisms resistant to penicillin, which is linked to its resistance to penitsillinaze. In addition, oxacillin remains active in the acidic environment of stomach that allows him not only intramuscularly, but inside.

     Oxacillin well absorbed from the gastrointestinal tract. He quickly allocated to the kidneys; For therapeutic concentrations in the blood it needs to be taken every 4 to 6 hours

     Applied oxacillin with infections caused by staphylococcus penitsillinazoobrazuyuschimi, resistance to dental and phenoxymethylpenicillin (septicemia, pneumonia, empiemy, abscesses, phlegmon, osteomyelitis, infected burns, wound infections, etc.). Preparation is also nominated in mixed infections, which are both sensitive and resistant to benzilpenitsillinam micro gram. When infection caused by staphylococcus, sensitive to benzylpenicillin, oxacillin a sodium salt inappropriate. The drug is effective in treating patients with syphilis.

     Assign inside, intramuscularly or intravenously.

     Inside appointed for one hour before eating or after 2 to 3 hours after eating. Under the dosage for adults and children over 6 years of age is 0.25 - 0.5 g, the average daily intake - 3 g. The heavy dose of infection increases (up to 6 to 8 g).

     Children under the age of 3 months appoint an average of 200 mg / kg / day, from 3 months to 2 years, 1 g / day, from 2 to 6 years to 2 g / day; The daily dose divided into 4-6 receptions. Next are on 90-150 mg / kg.

     If it is not receiving the drug inside or lack of effectiveness in such a way, appoint intramuscularly or intravenously. Daily intake for adults and children over 6 years of age, entered intramuscularly or intravenously, is 2 to 4 grams for newborn and premature babies-20-40 mg / kg; Up to 3 months-60-80 mg / kg; From 3 months to 2 years 1 g; from 2 to 6 years to 2 g. The heavy dose of infection can be doubled.

     For injecting solutions are ex tempore. For intramuscular injection enter into a bottle with 0.25 g oxacillin sodium salt 1, 5 mL, and 0.5 g-3 ml of sterile water for injection. For inkjet intravenously by dissolving 0.25 g of 0,5-preparation in 5 ml of sterile water for inektsny or isotonic sodium chloride solution and give a May 10 min, and the drip of dissolving medication in isotonic sodium chloride solution, or a 5% solution glucose an estimated 0.5-2, 0 mg in 1 ml and enter within 1 to 2 h (at speeds of 60-100 drops per minute).

     This treatment is usually 7 to 10 days, with heavy disease (sepsis, endocarditis septicheskny etc.), 2 -3 weeks or more.

     When treating oxacillin could experience allergic reactions. In some cases, possible nausea, vomiting, diarrhea. When expressed adverse events ceased temporarily or receiving drugs; If necessary, in conjunction with the sodium salt oxacillin designate protivogistaminnye preparations Glucocorticosteroids.

     Oxacillin is not suitable for high sensitivity to penicillin and allergic diseases.

     Method of issuance : in bottles of 0.25 and 0.5 g of the active substance (in terms oxacillin) together with the solvent (2 bottle of 0.25 g 2 injectable sterile water for injection or 2 feet of 0.5 grams of 4 injectable sterile water for injection of 2 ml); tablets of 0.25 and 0.5 g in a package of 20 pieces; capsules of 0.25 grams in a package of 10 and 20 capsules.

     Storage : List B. In dry, the dark place at room temperature.

Materials allowed to copy only with the active hyperlink to the handbook of medicines