OKSAZIL (Oxazylum).

     N, N'- Bis (2-dietilaminoetil) oksamida - bis - (ortho hlorbenzila dichloride).

     Synonyms : Ambenonil chloridum, Ambenonium cloride, Ambestigminum chloride, Mysuran chloride, Mytelase chloride and others.

     White melkokristallichesky powder. Gigroskopichen. The easily soluble in water, soluble in alcohol.

     Oksazil is symmetrical bis quarternary ammonium ground.

     Has strong antiholinesteraznoe (reversible) effect. The nature of close to prozerinu, but more active and more than length.

     Applied in infants, motor violations. related to carry meningitis or encephalitis, in the recovery period polio amiotroficheskom Lateral Sclerosis, central nervous system after injury, with peripheral facial nerve paralysis.

     Assign inside (after eating) in the form of tablets to 0,005 grams (5 mg). In infants begin to receive one pill, and then gradually increase the dose (adding 1 mg), watching the performance and portability drug. Usually single dose (for adults), 0.01 g (2 pills), but some patients need higher doses (3 or 4 tablets). Children drug designate smaller doses, depending on age. In light cases oksazil apply 1 to 2 times daily, in the heavy-5 - 6 times. The gap between tricks to avoid cumulation should be at least 4 hours When taken drugs before bedtime its effect on the length of the often remain until the morning.

     Signs of oksazila (increased movements and muscle strength, improved motion activity, a sense of lightness, etc.) are usually 0.5, 1, 5 h after administration. The effect of a single admission continues until May 10-hour or more, exceeding the duration of the prozerina (average 2 h after a single admission).

     When treating motor violations of the effects of polio, oksazil used in combination with other activities (gymnastics, physical therapy, water-treatment, etc.) in the early and late reconstruction period.

     Assign children aged 1 to 2 years to 0,001 - 0,002 grams (1 to 2 mg), 2 - 5-year-0,002 - 0,003 grams (2 to 3 mg), 6-to 10 - 0 , 003, 0,005 grams (3 to 5 mg), 11-14 years - 0,005 - 0,007 grams (5-7 mg), over 14 years - 0,007 - 0.01 g (7 - 10 mg); take every day. Depending on the effectiveness and acceptability of the drug may have ezhdnevno or through 1 - 2 days for treatment 15 20 receptions. Repeated courses through a 2 - 3 months.

     With motor violations after meningitis, encephalitis, CNS injuries, and facial nerve paralysis, and other motor violations appoint from 0,005 grams (5 mg) 2 - 3 times a day, changing the dose, depending on the effect and endurance. The course of treatment an average of 2 - 3 weeks. Children under 10 years appoint 0,001 g (1 mg) at one year of life per day (2 - 3 admission).

     Higher doses for adults inside : single 0,025 g (25 mg), daily 0.05 g (50 mg).

     Possible side effects and contraindications are the same as when applying prozerina.

     Product : pills to 0,001 g (1 mg); 0,005 g (5 mg) and 0.01 g (10 mg).

     Storage : A. In a list ukuporennoy packaging keeps from the world.

Materials allowed to copy only with the active hyperlink to the handbook of medicines