OKSIKOBALAMIN (Oxycobalaminum).

     For a [a - (5, 6 dimetilbenzimidazolil) - So b-oksikobamida hydrochloride.

     Dark red crystals or crystal powder. Gigroskopichen. Mg in the water, dry in alcohol.

     Is metabolite tsianokobalamina (vitamin 12). Is a structure of tsianokobalamina that the cobalt atom is not the Cyano, and oksigruppoy.

     On pharmacological properties and actions close to tsianokobalaminu; Compared with the last turning faster in the body into active kofermentnuyu form and remains in the blood longer, as more firmly associated with plasma proteins and slower out with the urine.

     Indications for use Tsianokobalamin see.

     Enter subcutaneously or intramuscularly.

     In various neurological diseases preparation introducing daily dose of 0.0002 g (200 µ g), 0.0005 g (500 µ g) daily for 10 to 20 days; In the treatment of diabetes mellitus with diabetic neuropathy-to 0.0005 g (500 µ g) per day for each day that a course of eight to 14 injections.

     When 12-scarce anemia apply to 0.0001 g (100 µ g) daily or every other day for 20 to 25 days, with the appearance of symptoms funikulyarnogo mieloza-to 0.0005 g (500 µ g) or 0,001 grams (1000 ug ) daily for 20 to 30 days. Dose for the maintenance treatment of 0.0001 g (100 µ g) 1 every 2 weeks during the 5 months, and then one every month.

     In the treatment of skin diseases oksikobalamin used in the daily dose of 0.0002 g (200 µ g) daily for 15 to 20 days, in severe cases, to 0.0005 g (500 µ g) a day for 10 days.

     Oksikobalaminom length of the treatment and the appointment of refresher courses depending on the nature of the disease and treatment.

     In applying the drug may allergic reactions. In these cases, it overturned and spend desensibiliziruyuschuyu therapy.

     Recently oksikobalamin found use as a antidote to cyanide poisoning, particularly in overdose nitroprussida sodium (see). Mechanism of antidotnogo oksikobalamina linked to the ability to interact with the free cyanide in the form of cobalt atom coordination tsianosoderzhaschy set, ie become tsianokobalamin (vitamin B 12).

     Application oksikobalamina therapy contraindicated in eritremii and eritrotsitoze as well as malignant and benign tumors, except megaloblastnoy deficiency anaemia and vitamin B12.

     Product : 0.01%; 0.05% and 0.1% in injectable solutions to 1 ml (100; 500 and 1000 µ g in 1 ml) in a package of 10 vials.

     The solution (pH 4, 3, 5, 0) - transparent liquid with a smell of acetic acid : 0.01% - pink, red-0.05%, 0.1% is dark red.

     Storage : in the dark spot.

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