PAKLITAKSEL (Paclitaxel).

     The substance of natural origin (C47H51NO14) - diterpenoid with a complex "taksanovym" core drugs.

     Synonyms: Abitaksel, Intaksel, Mitotaks, Taxol, Yutaksan, Intaxel, Taxol, Yewtaxan.

     First isolated in 1971 from yew tree bark Taxus brevifolia. Currently also receive polusinteticheskim and synthetic means. Chemical modification of a molecule paklitaksela close to the drug Docetaxel (taksoter), a few more activity.

     White or almost white crystalline powder. Nerastvorim water.

     On mechanism of cytostatic drug differs from alkaloids barvinka (vinblastina, vinkristina and kolhitsina) that not only inhibited, but also promotes education mikrotubul.

     Apply with ovarian cancer (including resistance to platinum), breast, lung, oesophagus and some other tumors.

     Assign intravenously in a long Infusion (3 or 24 h) in doses of 175-200 mg / m2 (with the combined treatment, 135-150 mg / m2) 1 every 3 weeks.

     Solution for Infusion produce 5% glucose solution and isotonic (0.9%) solution of sodium chloride concentration to 0,3-1,2 mg in 1 ml.

     In the application for the drug is often leukopenia or neutropenia, thrombocytopenia; Possible tachycardia, arterial hypotension, arrhythmia, arthralgia, joints, nausea, vomiting, diarrhea, peripheral neuropathy, disruption of the liver, vascular thrombosis bryzheechnyh, encephalopathy, paresthesia, history, allergic reactions.

     To improve portability to apoptosis glyukokortikosteroidami (dexamethasone) and antihistamines medications.

     Contraindications: leukopenia, infections, disruption of the liver, IBS, arrhythmia, pregnancy, breast-feeding.

     If getting solutions to the skin should be thoroughly washed with soap its water.

     Form release: 0.6% concentrate for Infusion in vials of 5, 17 and 35 mL.

     Storage: List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines