RAMIPRIL (Pamipril).

     1-Ethyl ether [1-karboksi-3- fenilpropil] - alanil] [b] oktagidrotsiklopenta pirrolo-2- - carboxylic acid.

     Synonyms : Korpril, Tritatse, Altace, Corpril, Tritace.

     The white crystalline powder. Mg in the organic solvent and water buffer solutions.

     Alaninsoderzhaschy ACE inhibitor for long periods (more than 24 h). The main pharmacological properties similar to other ACE inhibitors.

     Is prolekarstvom; After taking into metabolized in the liver to the active metabolite ramiprilat.

     When ingestion absorbed dose of 50-60%, Cmax is 1-4 h; Out with urine and faeces.

     Applied with arterial hypertension, congestive heart failure after myocardial infarction in diabetic nephropathy and. Individual patients are designated to prevent myocardial infarction, stroke, prevent death from cardiovascular disease and the need for revaskulyarizatsii attack.

     According to published abroad show that in patients with atherosclerotic peripheral vascular (without arterial hypertension, chronic heart failure and myocardial infarction in anamnesis) long (five years) use ramiprila lead to a decrease in the frequency of deaths, heart attacks primary attack, stroke and heart failure cases.

     Reducing mortality was also in the admission ramiprila IBS patients with acute heart attacks and congestive heart failure.

     With arterial hypertension and congestive heart failure used (inside) from 0.00125 grams (1.25 mg) one every day, if necessary daily dose increase at intervals of 1-2 weeks to 0.01 g (with heart failure, it can be divided into two sessions).

     Outgrowths sick appointed in the first two days of 0,00125-0,0025 g (1,25-2,5 mg), 2 times a day and then to 0,005 g, 2 times a day.

     To prevent myocardial infarction, stroke, death from cardiovascular disease and the need for revaskulyarizatsii attacks in some cases, to 0.0025 g (2.5 mg), 1 per day for 1 week, then 0,005 g (5 mg), 3 weeks and the remaining 0.01 g (10 mg).

     Possible side effects and contraindications are the same as those scored.

     Method of issuance : capsules and tablets for 0.00125; 0.0025 and 0.005 g (1.25; 2.5 and 5 mg) (N. 14, 28).

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