PAPAVERIN (Papaverinum).

     Alkaloid contained in opium. Currently, synthetic get through. Issued in the form papaverina hydrochloride (Rara verini from drochloridum h).

     On chemical structure is hydrochloride 6, 7 dimetoksi-1- (3, 4 dimetoksibenzil) - izohinolina.

     The white crystalline powder slightly bitter taste. Slowly soluble in water (1:40), little of alcohol. Aqueous solutions (pH 3, 0, 4, 5) to sterilize + 100 'C for 30 min.

     Papaverin is miotropnym spazmoliticheskim funds. It reduces the tone and reduces Oxytocics of smooth muscle and has therefore salts and skin effects.

     In high doses, reduces anxiety and heart muscle weakens vnutriserdechnuyu conductivity.

     Mechanism of papaverina not clear enough. In recent years, determined that he is fosfodiesterazy enzyme inhibitor and is Intracytoplasmic cyclical accumulation of 3 ', 5'- adenozinmonofosfata (see Theophylline).

     Accumulation tsAMF eventually breach the sokratimosti smooth muscles and relax with spasticheskih condition.

     Effects of dietary expressed weak, only bolshnh doses, it has a sedative effect.

     Papaverin widely used as a means of skin smooth muscle cramps in the abdomen (with pilorospazme, holetsistitah, spasticheskih colitis, cramps urinary track), bronchus (usually in combination with other Bronchiodialator means), and peripheral vascular cramps (endarteriite etc.) and vascular brain.

     Earlier, papaverin relatively widely used to prevent attacks inside stenocardia. The product has some effect, but is now used for that purpose better antianginalnye drugs.

     Sometimes papaverin used parenteral transmission (under the skin, intramuscularly, rarely in the veins), in conjunction with promedolom or other analgeziruyuschimi and spazmoliticheskimi kupirovaniya preparations for attacks stenocardia.

     Assign papaverina hydrochloride inside, under the skin, intramuscularly, intravenous and rectally.

     Inside adults take for 0,04 - 0,08 g (40-80 mg), 3 to 4 times a day; Children are also 3 to 4 times a day: at the age of 6 months to 2 years to 0,005 g ( 5 mg) for the reception, 3 to 4 years to 0,005, 0.01 g, 5 to 6 years of 0.01 g, 7 to 9 years - to 0.01 - 0.015 g, 10 - 14 year-to 0,015 - 0.02 grams per reception.

     When vomiting or swallowing zatrudenii appoint a theory of 0,02 - 0,04 g 2 - 3 times a day (adults).

     Under the skin and intramuscularly to introduce adults and 1 - 2 mL (often 2 ml) 2% solution, and intravenously in the same dose (slowly!) , Razbaviv 2% solution papaverina hydrochloride in 10-20 ml isotonic sodium chloride solution. Children are smaller doses of age.

     Higher doses for adults inside: single 0.2 g, 0.6 g daily; Under the skin, intramuscularly and veins: single 0.1 g daily 0.3 d.

     Higher doses for children inside the ages of 6 months to 1 year: single-0,005 grams daily, 0.01 g; At the age of 2 years off 0.01 g, 0.02 g daily; 3 - 4 years an 0,015 g, 0.03 g daily; 5 - 6 years off 0.02 g, 0.04 g daily; 7-9 years off 0.03 g, 0.06 g daily; 10 - 14 off-0.05 - 0.06 g daily 0.1 - 0.2 d. Children under 6 months are not appointed.

     In applying papaverina (often in high doses) may nausea, Constipation, headaches, increased sweatiness, and at very high doses, and the rapid introduction of intravenous-emergence aritmy, partial or full atrioventrikulyarnoy blockade.

     Contraindications: violations atrioventrikulyarnoy conductivity.

     Method of production: tablets of 0.04 g in the package of 10 pieces; 2% solution in ampoule of 2 ml; Candles of 0.2 d.

     Storage: List B. In sheltered from the world scene.

     There are also papaverina hydrochloride tablets for children was 0.01

     Accepted with cramps bowel, gall bladder and other conditions associated with cramps smooth musculature. Assign children from 6 months to 2 years of 1/4- 1 / 2 tablets; From 3 to 4 years to 1 / 2 - 1 tablet; 5 - 6 years and 1 tablet; 7-9 years - 1, 5 tablets; 10 - 14-1 5 2 tablets 3 - 4 times a day.

     Papaverina hydrochloride is often combined with various spazmoliticheskimi and sosudorasshiryayuschimi means. Following are ready combined pill: "Papazol, Nikoverin (see nicotine acid)," Andipal (see Analgin), "Bepasal (see Drugs crane)," Palyufin (see Platifillin), "Teoverin (see Theobromine), "Teodibaverin (see Theobromine), as well as tablets containing: a) papaverina hydrochloride and 0.02 g extract Blue 0,015 g; b) papaverina gidrohdorida and 0.02 grams of phenobarbital, platifillina gidrotartrata 0,003 g; c) papaverina hydrochloride 0.02 g platifillina gidrotartrata 0,005 city

     Released earlier combined pill containing papaverin: "Kellatrin, Kelliverin, Lyupaverin," excluded from the range of medicines.

     Pills "Papazol (Ta bulettae" Rara zolum ") contain 0.02 grams papaverina hydrochloride and dibazola. Apply with moderately expressed cramps peripheral vessels, vascular brain lighter hypertensive disease.

     Assign 1 - 2 - 3 2 pills twice a day.

     Storage: List B.

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