PARMIDIN (Parmidinum).

     Bis-N- metilkarbaminovy ether 2, 6-bis oksimetilpiridina or 2, 6-bis piridinil- (metil-N- methyl carbamate).

     Synonyms : Anginin, Piridinolkarbamat, Prodektin, Acesterol, Andil, Anginin, Angiovital, Angioxine, Angioxyl, Aterofal, Aterokin, Atover, Cicloven, Colesterinex, Duaxol, Duvaline, Eluen, Exibral, Garparol, Katrombin, Prodectin, Pyridinolcarbamat, Ravecil, Sospitan, Vasagin, Vasapril, Vasocil, Vasoverin, Veranterol and others.

     White or almost white crystalline powder. Little is soluble in water, it is difficult to alcohol.

     Parmidin has angioprotektornoy activity reduces vascular permeability, the recovery of disturbed microcirculation in pathological processes. Much of this is due to the influence of kinin- kallikreinovuyu system, especially with the reduction of activity bradikinina. It also reduces the aggregation of platelets, stimulates fibrinogenez.

     Originally parmidin (anginin) has been proposed as a means antiskleroticheskogo. As antagonist bradikinina it reduces reduction endotelialnyh cells of arteries, as well as the intervals between them, and thus prevent infiltration into inner shell aterogennyh vascular density. With antiinflammatory activity parmidin also reduces swelling endotelialnyh cells, preventing lipid infiltration lining vessels, and to reverse infiltrative changes in the development of atherosclerosis. He has also gipoholesterinemicheskoy moderate activity.

     As a means of self antiskleroticheskoe parmidin not currently used, but it is widely used as a means of combination therapy in the treatment of atherosclerotic vascular brain, heart, limbs, and when ateroskleroticheskoy angiopatii diabetes, retinal vein thrombosis, obliteriruyuschem endarteriite, trophic ulcer limbs. Best results are seen in the peripheral vascular lesions, especially vascular lower limbs in diabetic angiopatiyah, mainly diabetic retinopathy. There is evidence of positive effects of the drug on the stomach and pancreas diabetes, as well as whether parmidina (prodektina) in the treatment of patients with pulmonary tuberculosis. The drug speeds up the disappearance of the symptoms of intoxication and resorption infiltrates in the lung. Improved portability of TB chemotherapy drugs.

     Parmidin be combined with vitamins, enzymes, kofermentami, if necessary with antidiabetics drugs (with diabetes angiopatiyah). There is a strong tendency to normalize lipid exchange with chronic IBS admission parmidina (prodektina) combined with lipoevoy acid.

     Assign parmidin inwards from 0.25 g (1 tablet) 3 - 4 times a day. Then, with good endurance to increase the dose of 0.75 g (3 tablets) 3 - 4 times a day. Usually a daily dose of 1 to 2 g. The course of treatment is from 2 to 6 months or more.

     Parmidin effective in treating common neyrodermitov. In the therapeutic effects of the drug (stop itching, skin erythema regression, etc.) play a role, apparently, it antibradikininovye properties. The agent designated in normal doses. The course of treatment 14 to 30 days.

     Parmidin usually well. In several cases, nausea, allergic skin reactions, headaches, as well as increasing transaminaz liver; In extremely rare cases, development gepatitopodobnoy reaction.

     Usually, adverse reactions were dose reduction in or elimination of the drug.

     In violation of the functions of the liver drug contraindications.

     For external use of a 5% ointment parmidina (Unguentum Parmidini 5%), containing parmidin, lanolin, glycerin, emulsifier and other supporting material. Ointments white with cream flavor, to a specific smell.

     When applied ointment neyrodermite, skleroatroficheskom lihene (kaplevidnaya sclerodermia) genitals of children, as well as preventive and therapeutic means of ray lesions.

     In neyrodermite ray and defeat ointment cause thin layer of areas affected, vtiraya slightly, 2 to 3 times a day for 10 to 15 days. In skleroatroficheskom lihene use long (up to 4 months).

     In neyrodormite and skleroatroficheskom lihene place on top of masi fold from wax paper. To prevent losses in radiation therapy cause thin layer of ointment and rubbing in the fields of radiation for 30 minutes before the session, and for the treatment of dermatitis ray 2 - 3 times a day for 10 to 12 days.

     In developing allergic reactions in all cases ointment overturned.

     Method of production : tablets of 0.25 g banks orange glass; Ointment 5% to 30 grams of aluminium tubes or glass banks, and 500 g of glass banks.

     Storage : pills, in the dark places; Ointment, in a cool place; Protect from freezing.

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