PEFLOKSATSIN (Pefloxacinum) *. 1-Etil-6- fluorine-1, 4-dihydro (4-methyl piperazine) -4 - oxo hinolinkarbonovaya acid.

     Synonyms : Abaktal, Abaktal, Peflacine, Pefloxacin.

     Pefloksatsin a typical structure ftorhinolonom containing the situation hinolonovogo 6 fluorine atom nucleus, and one 7-metilzameschenny piperazinil.

     The drug has a broad spectrum antibacterial action. Mostly affects gram bacteria, but gram anaerobic bacteria resistant to its actions.

     The drug is effective oral and parenteral application. If ingestion is rapidly absorbed, the maximum concentration in the blood is at 90 min after administration. The half about 8 hours

     Preparation is well into the organs and tissues, including brain, bone, mucous membranes, etc.

     Provided mainly kidneys unchanged, partly in the form of metabolites.

     Applied pefloksatsin infection in the respiratory tract, ear, throat, nose, skin, infectious diseases, kidney, urinary tract, abdominal, gynecological infectious diseases, wounding and other infections caused by bacteria susceptible to the drug.

     Inside designate adults and 1 tablet (0.4 g), 2 times a day (morning and evening) during food.

     The duration of treatment is usually 7 to 14 days. Parenteral (slow intravenous cefuroxim) imposed on 400 mg (1 capsules contents size of 5 mL), divorced in 250 ml 5% glucose solution. This dose imposed within 1 hour and 2 times a day (morning and evening). It introduced the drug solution of sodium chloride or other solvents containing chlorine ions.

     In especially difficult during the disease can begin with the introduction of 800 mg (2 capsules) drug.

     Possible side effects, precautions and contraindications are basically the same as for the other 6-ftorhinolonov (see Ofloksatsin).

     Method of production : tablets of 0,4 g of 5 ml ampoules containing 0.4 g pefloksatsina (as mezilata- digidrata).

     Close on the structure of a drug pefloksatsinu norfloksatsin (Norfloxacin).

     Synonyms : Nolitsin, Baccidal, Barazan, Buccidal, Espeden, Floxacin, Fulgram, Lexinor, Negaflox, Nolicin, Nilion, Norocin, Noroxin, Primoxin, Uroctal, Zoroxin and others.

     Is pefloksatsina lack of methyl groups in piperazinilnom kernel.

     On mechanism of close to pefloksatsinu. Is pefloksatsina metabolite, in the application of which the urine out in large numbers norfloksatsin.

     Product : pills to 0.4 g.

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