PENTAMIN (Pentaminum).

     K - Methyl-1, 5-bis - (N, N - ethyl ammonium dimetil-N-) -3 - azapentana dibromide.

     Synonyms : Azamethonii bromidum, Azamethonium bromide, Pendiomid, Pentamethazene and others.

     White or slightly yellowish sheen crystalline powder. Very gigroskopichen. The easily soluble in water and alcohol. Aqueous solutions are sterilized at + 100 C for 30 min; 5% solution of pH 6, 0, 7, 5.

     Pentamin to symmetrical bischetvertichnym ammonium compounds.

     Indications are basically the same as for other similar ganglioblokatorov (see Benzogeksony). There is considerable experience in effective application pentamina PNDS crises, peripheral vascular spasm, intestinal cramps and biliary tract, renal colic, bronchial asthma (mild acute), and eclampsia, kauzalgiyah in light swelling, swelling of the brain.

     In practice Urology pentamin apply to tsistoskopii men to facilitate tsistoskopa passing through the urethra. In practice anaesthetics used for the controlled hypotension.

     When cramps and other vascular diseases start with a 1 ml of 5% solution, and then increase the dose to 1, 5 to 2 mL 2 - 3 times a day. Enter intramuscularly.

     In PNDS crises, swelling of the lungs, swelling of the brain give vein 0,2 0,5 ml or more than 5% solution, divorced in 20 ml isotonic sodium chloride solution, or 5% glucose solution. Enter slowly under control and AD general. It is injected intramuscularly 0,5-2 ml 5% solution.

     To run hypotension give veins before surgery 0,8-1, 2 ml of 5% solution (40-60 mg), as appropriate to impose dopolnitlno total dose of 120 to 180 mg (2, 4, 3, 6 ml of 5% solution) .

     Higher doses of adult intramuscularly : single 0.15 g (3 ml of 5% solution), 0.45 g daily (9 ml of 5% solution).

     Possible side effects and contraindications are the same as for the entire group ganglioblokiruyuschih drugs.

     Product : 5% solution in ampoules of 1 and 2 ml.

     Storage : List B. In the dark spot.

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