PENTOKSIFILLIN (Pentoxyphyllin) *. 3, 7-Dimetil-1- (5-oksogeksil) - ksantin or 1-(5-oksogeksil) Theobromine.

     Synonyms : Agapurin, Trental, Agapurin, Oxpentifylline, Pentoxifyllin, Ralofekt, Terental, Torental, Trental.

     The white crystalline powder. Mg in the water.

     On chemical structure similar to teofillinu and teobrominu.

     The preparation and improves blood flow properties. Has salts and improves the supply of oxygen to tissues. Adenozinovye block receptors. Ingibiruet fosfodiesterazu and promoted the accumulation of platelets tsAMF. Decreases platelets aggregation and disaggregation resulted in increases elasticity (deformability) erythrocyte reduces the viscosity of the blood.

     The drug is rapidly absorbed. The peak concentration in plasma was through one hour after administration of the interior. By 8 th hour concentration decreased significantly (up to 10% of the primary). There were mostly in the form of non-toxic metabolites kidneys.

     Pentoksifillin applied to violations of peripheral blood (endarteriit illness Reyna, etc.) and cerebrovascular disease (ateroskleroticheskie violations ischemic condition, post-heart attack, etc.), vascular pathology eyes, and other tissues nefroangiopatii diabetic angiopatiyah, functional disorders of hearing.

     The drug is effective in IBS, coupled with mikroangiopatiey sclerotic or diabetic origin. But medication has expressed antianginalnoy activity.

     Assign pentoksifillin inside, and vnutriarterialno intravenously. Inside are from 0.2 g (2 pills) three times a day after meals, not liquid (There is an interest in increasing daily doses of 800-1200 mg.) . After the therapeutic effect (usually 1 to 2 weeks) to reduce the dose of 0.1 g (1 tablet) three times a day. The course of treatment 2 to 3 weeks or more.

     If necessary (or severe violations of peripheral blood-brain ischemic stroke) or injected vnutriarterialno. Enter 0.1 g intravenously (1 vials) in the 250-500 ml isotonic sodium chloride solution, or 5% glucose solution over 90,180 mines. Daily intake can be further increased to 0.2 - 0.3 g. Vnutriarterialno introduce first 0.1 g product in 20 to 50 ml isotonic sodium chloride solution in the next few days - to 0.2 - 0.3 g ( 30-50 mL solvent). Enter a speed of 0.1 g (5 mL of 2% solution of preparation) for 10 minutes.

     When ingestion possible diarrhoeal phenomenon, nausea, dizziness, Blush person; Parenteral with a lower-AD.

     Contraindications : acute myocardial infarction, massive bleeding, severe coronary atherosclerosis and vascular vascular brain. In far comes atherosclerosis brain drug can be introduced into sleepy artery. In an application antidiabetics and antigipertenzivnyh drugs pentoksifillina dose should be reduced.

     The drug should not be used in pregnancy.

     Method of issuance : pills (pills pinks) to 0.1 g in a package of 60 pieces; 2% solution of 5 ml ampoules in a package of five vials.

     Storage : List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines