FENTANIL (Phentanylum). 1-(2-Feniletil) -4 - (N-propionilfenilamino) - piperidine.

     The white crystalline powder. Nerastvorim almost in the water. Easy soluble in alcohol.

     Issued in the form of citrate (Phentanyli citras, Phentanylum citricum).

     Synonyms: Sentonil, Fentanil, Fentanylcitrat, Fentanyli citras, Fentanyl citrate, Fentanest, Haldid, Leptanal, Sentonyl, Sublimaze.

     Fentanyl is a synthetic analgetikom, fenilpiperidina derivatives. As part of the chemical structure similar to promedolom. Provides strong, but short-term (with an introduction) analgesic effect.

     After intravenous maximum effect is via 1 - 3 minutes and lasts 15 to 30 minutes. After vnutrimyshechnogo a maximum effect comes through 3-10 min.

     Apply mainly for neyroleptanalgezii with brain (see Droperidol). Is part of a combined drug talamonal (see).

     For medicinal preparations for anaesthesia (apoptosis) in the dose of fentanyl imposing 0.05-0.1 mg (1 - 2 mL of 0.005% solution) intramuscularly for half an hour before the operation.

     To neyroleptanalgezii tentatively set adjunct, then fentanyl per 1 ml of 0.005% solution for every 5 kg body weight patients. Enter intravenous drug slowly. For induction anaesthesia can be used twice smaller doses of fentanyl, followed by small doses of barbiturates or other means to narcosis (combined induction).

     Typically, after adjunct and enter patient exhibited muscle Relaxant, intubiruyut box and to support or artificial lung ventilation with oxygen or a mixture of oxygen with nitrogen oxide inhalation or other anaesthetics in small concentrations. To maintain analgezii imposed if necessary every 10 to 30 minutes extra 1-3% 0,005 ml solution exhibited.

     In short vnepolostnyh operations, which do not require the use of the muscles and Judge neyroleptanalgeziya a conservation spontaneous respiration, fentanyl imposed at the rate of 1 mL of 0.005% solution for every 10 to 20 kg body weight. It should monitor the adequacy of spontaneous breathing. There is a need to be able to make, if necessary tracheal intubation, and artificial lung ventilation. In the absence of conditions for the use of artificial ventilation lung exhibited for neyroleptanalgezii unacceptable.

     When operations under local anesthesia fentanyl (usually in combination with neyroleptikom) can be used as an additional means of pain. Enter intravenously or intramuscularly 0.5 to 1 mL of 0.005% incidence solution (if necessary a drug can be repeated every 20 to 40 minutes).

     Fentanyl can be used to address severe pain in a heart attack Chavez, stenocardia, heart attack lung, kidney and liver colic. Enter intramuscularly or intravenously 0.5-1 - 2 mL of 0.005% solution. Fentanyl is often used for this purpose, together with neyrolepticheskimi drugs.

     Repeat injections exhibited in 20-40 minutes, and after surgery through 3-6 hours

     In applying the incidence, particularly with the rapid introduction of veins may respiratory depression, which can be removed intravenous naloksona (see).

     Are there propulsion arousal, muscle spasm and stiffness chest and limbs, bronhiolospazm, hypotension, sinusovaya aetiology. Aetiology eliminated atropine (0.5-0.1 mL of 1% solution).

     The use of fentanyl counter with a caesarean section operation (until extraction of the fetus), and other obstetric operations (due to increased sensitivity to determine incidence of neonatal respiratory center), and expressed hypertension in a small circle of blood and oppression respiratory center, pneumonia, atelectasis, and heart attack light, bronchial asthma, the propensity to bronhiolospazmu, ekstrapiramidnoy system diseases.

     Patients, lechennym insulin, stimulation and gipotenzivnymi means introducing smaller doses.

     By fentanyl can develop addictive and painful addiction.

     Form release: 0.005% solution in ampoule of 2 and 5 ml.

     Storage: A. Leave the list and make use of the rules established for morphine and other drugs analgetikov.

     Due to high drug with him (in the workplace) should be careful (to work in space, power, the gloves).

Materials allowed to copy only with the active hyperlink to the handbook of medicines