Fenilsalitsilat (phenylii salicylas)


FENILSALITSILAT (Phenylii salicylas).
     Fenilovy salitsilovoy acid ester.
     Synonyms: Salol, Phenylium salicylicum, Salolum.
     The white crystalline powder or small colorless crystals with low odor. Almost nerastvorim water soluble (1:10) in alcohol, caustic alkali solution.
     Fenilsalitsilat (salol) was synthesized long (1886, L. Nentski) with the aim of creating a drug that is not broke would zhedudka acid content and not acted irritatingly mucosal lining of the stomach and rasscheplyayas in alkaline content bowel, vysvobozhdal a digestive acid and phenol. Phenol would act gradually on the pathogenic micro bowel, salicylic acid has a slight Analgesic and anti effect, and both compounds vydelyayas part of the body's kidneys, dezinfitsirovali would pool ways.
     This principle (<salolovy> principle Nentski) essentially was one of the first experiments of Prokopenko (prodrug) (see also Geksametilentetramin).
     Long time fenilsalitsilat widely used in bowel diseases (colitis, ac), with cystitis, pielitah, averages.
     More modern antibacterial drugs: antibiotics, sulfanilamidami, ftorhinolonami and others - fenilsalitsilat much less active. However, he malotoksichen, is disbakterioza and other complications and is sometimes used in the outpatient practice (often in conjunction with other means) in light of these diseases. When expressed more forms of diseases to use more drugs.
     Assign fenilsalitsilat inside of 0.25 - 0.5 grams per reception 3 to 4 times a day, often in conjunction with spazmoliticheskimi courses and other means.
     Form release: powder, pill to 0.25 and 0.5 g and various combination pill: a) tablets <> (Besalol Tabulettae <Besalolum>); A: fenilsalitsilata 0.3 g, 0.01 g Blue extract; B) pills <> (Urobesal Tabulettae <<Urobesalum>>); a: fenilsalitsilata and geksimetilentetramina to 0.25 g, 0,015 g of extract crane; c) tablets <<Tansal>> (Tabulettae <Tansalum>); a: fenilsalitsilata and tanalbina of 0.3 g; g) fenilsalitsilata and bismuth nitrate mainly to 0.25 g extract Blue 0,015 city
     Fenkortozol (Phencortosolum). Contains fenilsalitsilat and hydrocortisone acetate. Implemented as fotozaschitnogo and anti funds when fotodermatozah, diskoidnoy red lupus. The course of treatment 7 to 10 days. If necessary, repeat treatment in 5 to 7 days.
     Form release: emulsion in aerosol containers with a capacity of 55 g.
     Clicking on the cylinder valve within 1 - 2 goes from 7 to 14 cm foam (0.7, 1, 4 g foam), sufficient to cover 500 cm ~ surface skin. Simultaneously can cause the skin to 30 cm 'foam. Pena evenly back in the skin massage movements.
     Do not apply product sunny days in the cold season.
     Storage: at temperatures higher than 40 C.

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