FOPURIN (phopurinum). 6-Dietilenimidofosfamido-2- dimetilamino-7- metilpurin.

     Synonym: Pumitepa.

     White or white with a slightly greenish-yellow tints crystalline powder. Soluble in water and alcohol.

     According to the structure of the product on the one hand, close to antimetabolitam Purina, on the other hand, is a compound containing alkiliruyuschie Group (etilenimina).

     The product has antitumor activity whereby the predominantly leykoznogo ability to suppress the development process. In small doses, the drug moderately oppresses blood, but in large doses can cause expressed leyko- and thrombocytopenia.

     Apply fopurin with acute leukemia, chronic mieloleykoze with skin retikulezah and retinoblastoma.

     Enter fopurin intravenously or intramuscularly.

     In acute leukemia impose daily from 40 mg, then with a good dose of portability gradually increase to 10-20 mg to 120 mg (for adults). Exchange dose is 1 to 3 was designated for children 5 to 30 mg once a day; Treatment of 0,5 - 0,7 g.

     When skin retikulezah (mushroom avium, angioretikulez Kaposi etc.) enter each day, starting with 20 mg and, carrying up to 120 mg dose. At treated 1.5- 3. 0 g.

     In retinoblastoma drug impose daily intramuscularly, ranging from 5 mg dose and bringing to 40 mg; Throughout the course of 45 injections.

     Apply fopurin usually in combination with other protivoopuholevymi means, and, if necessary, surgical treatment and radiation therapy (with retinoblastoma).

     For content ampoule injection (40 mg) with fopurinom dissolve in isotonic sodium chloride solution, sterile water for injection, or 0.5% solution of Novocaine (in vnutrimyshechnom introduction). Dissolving drugs has been slow.

     In applying fopurina possible headache, dizziness, diarrhoeic phenomenon fall, allergic phenomena ortostaticheskaya hypotension (hence, the patients after intravenous drug should be within 1 - 1 5 h in a horizontal position).

     Vnutrimyshechnoe a drug dose is acceptable only if no more than 60 mg, as well as the introduction of the drug in higher doses by the pain of making at the injection site.

     In high doses fopurina or high sensitivity can leukopenia and thrombocytopenia. In these cases to the same activities as the oppression of blood from other ANTITUMOR drugs.

     Fopurin contraindications for violations of the liver and kidneys, with significant radiation and thrombocytopenia in terminal condition.

     Form release: fonurin sufficient for injection (Phopurinum lyophilisatum 0.04 p ro inj EU tionibus) - white or white with a slightly yellowish tinge porous mass or 0.04 grams of powder in sealed ampoule in the package of 10 vials.

     Storage: List A. sheltered from the world scene with a temperature higher than + 10 C.

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