PIOGLITAZON (Pioglitazone).

     5-[4-[2 - (5-Ethyl piridinil) etoksi] phenyl] methyl] -2,4 - tiazolindiona hydrochloride.

     Synonym : Actos, Actos.

     It increases sensitivity to insulin tkaney- targets and reduces glucose output from the liver.

     Rapidly absorbed, C max was 2 h, T? h-3-7 (16-24, the metabolites h); being in the liver biotransformation education 2 active metabolites appears mostly with bile.

     Applied (singly or in combination with sulfanilamidnymi drugs, metformin, insulin-dependent) diabetes type II.

     Assign inside (regardless of meal times), since 0,015-0,03 g doses (15-30 mg) one time a day if necessary, increasing it to 0,045 g.

     Possible side effects : gipoglikemicheskie reaction, swelling, anaemia, allergic reactions.

     Contraindications : the same as that of repaglinida.

     Product : pills to 0,015 and 0.03 g (15 and 30 mg).

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