PIPERATSILLIN (Piperacillin).

     Synonyms : Isipen, Pipraks, Pipratsil, Pitsillin, Picillin, Pipracil, Piprax, Ysipen.

     Available in the form of sodium salt.

     White or almost white solid. The easily soluble in water.

     Semi antibiotic from the penitsillinov. Contains molecules in the replacement group piperazine (hence the name-piperatsillin).

     It has a wide range of activity. Active against gram and gram bacteria obligatnyh anaerobov, klostridy. Destroyed? - Laktamazami staphylococcus bacteria and some gram, but is effective against gonokokkov, produce? - Laktamazy.

     Piperatsillin like azlotsillinu and karbenitsillinu, for the so-called antisinegnoynym penitsillinam.

     After intramuscular of C max for 30 min, T? - 35-70 minutes; pervades all bodies and body fluid; displayed mostly kidneys unchanged. If ingestion is not absorbed.

     Applied with heavy infection (mostly sinegnoynyh) abdominal, lower respiratory tract, urinary tract and zhelche-, LOR- organs, skin, soft tissues, bones and joints, and sepsis, endocarditis and other infectious processes.

     Enter intravenous slowly (for 3-5 min) drip on 0,1-0,15 g / kg / day (3-4-admission), with heavy infection to 0,2-0,3 mg / kg day, a life-threatening up to 16 grams a day. Enter during 3-10 days.

     Possible side effects : diarrhoeal phenomenon holestatichesky hepatitis, drowsiness, parestezii, radiation, neutropenia, thrombocytopenia, hemorrhagic complications, goiter, candidiasis, allergic reactions, in a place - flebity, infiltrates.

     Product : powder for injection solutions in bottles of 1, 2, 3 or 4 years

     Piperatsillin a key component combined antibioticheskogo drug tazotsin resistant to? - Laktamazam.

     Storage : List B.

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