PIRIBEDIL (Piribedil)

     Chemical name : 2-[4 - (1,3-Benzodioksol-5- ilmetil) -1 - piperazinil] Pyrimidine (in the form of monometansulfonata)

     Pharmacology : The drugs act-protivoparkinsonicheskoe.

Is agonist dofamine receptors. Dofamine stimulates receptors in the central nervous system, mainly in the nucleus ekstrapiramidnoy system. Increases blood brain tissue, consumption of oxygen improves brain metabolism. It stimulates the transfer of nerve impulses, increases the electrical activity of neurons crust (as in waking, and during sleep). Institute dofamine peripheral receptors in vascular smooth muscles and provides vazodilatiruyuschee effect.

Rapidly absorbed from the digestive tract. Cmax achieved through 1 hour, tying with low plasma proteins. Biotransformiruetsya in the body into two major metabolites. T1 / 2 (two-) is 1,7-6,9 hours Write mostly kidneys (68% in the form of metabolites), and bile (25%).

     Application : Violation of cognitive function and neyrosensorny deficit in the ageing process; Parkinson's disease - monotherapy (with the forms, which include tremor), or in combination with levodopa; "Peremezhayuschayasya" limp (obliteriruyuschie artery disease); Ischemic symptoms ophthalmic diseases.

     Contraindications : Giperchuvstvitelnost, arterial hypotension, collapse, myocardial infarction (acute phase), pregnancy, breast-feeding.

     Application of pregnancy and breastfeeding : Protivopokazano pregnancy (adequate and well-controlled studies on the use during pregnancy is not held) and during lactation.

     Side Effects : Anxiety and stir; Orthostatic hypotension; Nausea, vomiting, flatulence.

     Networking : Antagonisty release, including neuroleptic (PHENOTHIAZINES, butirofenony, tioksanteny) and metoclopramide, may reduce the effectiveness of (mutual).

     Overdosing : The symptoms : vomiting.

Treatment : symptomatic therapy.

     Dosing and Administration : inside, after eating, 50 mg / day at a time, by 50 mg 2 times a day. Parkinson's Disease : monotherapy, 150-250 mg / day for 3-5 receptions; In combination with levodopa-100-150 mg 2-3 reception.

     Precautions : In patients with elevated AD requires additional anti-hypertensive therapy.

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