PLATIFILLIN (Platyphyllinum).

     Alkaloid platifillin in krestovnike rombolistnom or shirokolistnom [Senecio rhombofolius (Willd.)], syn. Senecio platyphyllus D.C., herewith. Asteraceae (Compositae).

     Refers to geliotridana derivative (1-methyl pirrolizidina).

     In clinical practice using platifillina gidrotartrat (R latyphyllini hydrotartras).

     Synonym : Platyphyllinum hydrotartaricum.

     The white crystalline powder bitter taste. The easily soluble in water (1:5 in the hot, 1:10 in the cold), very little in alcohol; PH 0.2% solution of 3, 6, 4, 0. Solutions are sterilized with 100 'C for 30 min.

     Platifillin has holinoliticheskoe effect. The effect on peripheral holinoreaktivnye system similar to atropine. In less active than atropine, but no less relevant doses of atropine on; Better postponed. Worst than atropine, injures holinoreaktivnye vegetative nervous system nodes. At the central nervous system, especially at sosudodvigatelnye points, has a soothing effect. It has also apparent (papaverinopodobnymi) properties.

     Assign smooth muscle cramps in the body cavity, stomach ulcers and gastrointestinal cancer, bronchial asthma; Preparation also reduces spasm of blood vessels (in hypertensive disease, strokes), cramps stroke.

     In ophthalmic practice used to improve pupil. Relatively with atropine impact on the accommodation little noticeable. Step on the tail length less than the atropine and gomatropina (see).

     For edema more acute ulcer and gastric, liver, renal colic platifillin imposed under the skin on 1 ml of 0.2% -2 solution. For a course of treatment (10 - 15 - 20 days) designate inside (to food) to 0.00 W, 0,005 grams or 10 to 15 drops of 0.5% solution of 2 - 3 times a day or are under the skin on 1 - 2 ml 0.2% solution. The drug may be nominated in candlelight to 0.01 g 2 times a day or mikroklizme to 20 drops of 0.5% solution of 1 - 2 - 3 times daily. In Ophthalmic Practice 1% solution used for diagnostic purposes and 2% solution for therapeutic purposes.

     Children appoint 0.0002 g (0.2 mg), 0,003 g (3 mg) to receive, depending on age.

     Higher doses for adults inside and under the skin : single 0.01 grams daily 0.03 g.

     Overdosing platifillina may cause the same thing as atropine overdose (dry mouth, rapid heartbeat, increased pupil, bringing central nervous system, etc.).

     Contraindicated in glaucoma, as well as organic liver and kidney diseases.

     Method of issuance : powder; Tablets of 0,005 grams (5 mg); 0.2% solution of 1 ml ampoules.

     Storage : A. In a list ukuporennoy packaging.

     Rp. : Tab. Platyphyllini hydrotartratis 0,005 N. 6

     D.S. At one pill 2 - 3 times a day

     Rp. : Platyphyllini hydrotartratis 0.005

     Papaverini hydrochloridi 0.02

     D.t.d. N. 10 in tab.

     S. At one pill 2 - 3 times a day

     Rp. : Platyphyllini hydrotartratis 0,003

     Three P v e rini hydrochloridi 0.03

     T he on bromini 0.25

     D.t.d. N. 10 in tab.

     S. At one pill 2 - 3 times a day (at angiospazmah)

     R p. : S for l. R A and a ph of the llini h in 0.2% drotartratis 1 ml

     D.t.d. N. in ampull 10.

     S. 1 ml subcutaneously for 2 times a day

     R p. : S for l. P l and t s h a llini h from drotartratis 0.5 ml 20%

     D.S. Inside of 10 drops 2 times a day

     R p. : Sol. P l and t s h a llini h from drotartratis 1% (2%) 10 ml

     D.S. The eye drops (to improve pupil)

     Pills "Tepafillin (Ta bulletae" The records have llinum h).

     Ingredients : platifillina gidrotartrata 0,003 grams papaverina hydrochloride and phenobarbital to 0.03 g, 0.25 teobromina city Spazmoliticheskoe, holinoliticheskoe, salts funds. Assign to one pill 2 - 3 times a day (list A).

     Pills "Palyufin (Ta bulettae" Ra lufinum "). Ingredients : platifillina gidrotartrata 0,005 grams of phenobarbital and papaverina hydrochloride 0.12 for the city and Spazmoliticheskoe holinoliticheskoe funds. Assign 1 2 3 tablets twice daily (list A).

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