PIRAZIDOL (Pyrazidolum). 2, 3, Za, 4, 5, 6-methyl-1 Geksagidro-8- H pirazino- [3, 2, 1-j, k] - karbazola hydrochloride, or 1 10-trimetilen-8- methyl-1 2, 3, 4-tetragidropirazino [1, 2] - indole hydrochloride.

     Synonyms : Pirlindol, Pirlindolum, Pirlindole.

     White with yellow or greenish white crystalline powder. Nerastvorim almost in the water.

     Pirazidol is original domestic antidepressant drug. The structure is different from other antidepressants that is chetyrehtsiklicheskim connections. This product indole with elements of the structural similarity to serotonin, as well as rezerpinom and other condensed indolnymi derivatives.

     Pirazidol has expressed antidepressant activity, a feature it is a combination timolepticheskogo effect of the regulatory impact on the central nervous system, in terms of the activating effects in patients with apaticheskimi, anergicheskimi depression and sedative effects in patients with azhitirovannymi state. To some extent, has also pirazidol nootropnoy activity and improves cognitive functions (cognitive).

     In anxyolitics mechanism of action pirazidola major role played by his influence on the content and the exchange of CNS neyromediatornyh monoaminov.

     This was primarily due to its inhibiting effect on MAO activity. Features pirazidola selective inhibition of MAO-A type, which is short and completely reversible. This was significantly different from the indiscriminate, irreversible MAO-inhibitors group iproniazida.

     Consider varying degrees of inhibition pirazidolom deamidization monoaminov different. He is blocking deamidization serotonin and noradrenalina and relatively little impact on deamidization tiramina that produces less prerequisite for the development of "cheese" syndrome. Pirazidol ingibiruet also partially reverse takeover monoaminov that brought him to a certain extent with tricyclic antidepressants. Together pirazidola application leads to significant activation of synaptic transmission in the central nervous excitation.

     Pharmacologically pirazidol is close to the depressive effects rezerpina, potentiation of fenamina, L-Dov, 5-oksitriptofana. Unlike tricyclic antidepressants pirazidol no antiholinergicheskogo action.

     Assign pirazidol patients with manic depressive, with schizophrenia and affective disorders involyutsionnym psychosis, occur with depression. Preparation is shown in depression with psychomotor slowing, as well as depression, anxiety accompanied by depression and anxiety raving components anesteticheskoy, ipohondricheskoy and nevrozopodobnoy symptoms.

     Patients alcoholism, especially during abstinence, pirazidol nominate to reduce depression and anxiety repressive states.

     In connection with a positive impact on cognitive functions pirazidol may be useful in the treatment of senile dementsy (Alzheimer's, etc.).

     You can combine with pirazidol Neuroleptics, tranquilizers.

     Assign pirazidol into tablets. Treatment starts with 50-75 mg (0.05 - 0,075 grams) per day for 2 admission, gradually increasing the dose to 25-50 mg. Usually, the therapeutic effect is achieved by July 14 th day care through a dose of 150-300 mg per day. If necessary, and good endurance daily dose may be increased to 400 mg. Upon reaching the therapeutic effect of treatment continue individually calibrated doses for the next 2 to 4 weeks, after which the dose gradually.

     When neurotic and reactive depression drug is used in lower doses.

     Pirazidol usually well. Lack of holinoliticheskogo can apply it in patients who can not receive antidepressants with holinoliticheskoy activity (with glaucoma, prostate gland adenoma, etc.), such as amitriptyline, hydrochloride, etc. In the rare cases when high sensitivity can be observed small dry mouth, sweating, tremor hand, tachycardia, nausea, dizziness. These phenomena are rapidly declining doses.

     Good portability allows pirazidol in patients with concomitant physical illness. There is evidence of the use of pirazidola in treating depression in patients with strokes.

     The drug is contraindicated in acute inflammatory liver diseases and diseases haematopoietic system.

     Do not assign pirazidol with antidepressants, MAO inhibitors. After pirazidol MAO inhibitors may be nominated by two weeks. In connection with antimonoaminoksidaznoy drug activity should take into account the possibility of increased response to adrenaline and other simpatomimeticheskie amines if a patient during a pirazidola. If there is no urgent need to introduce these drugs during treatment pirazidolom not recommended.

     Product : pills to 0,025 and 0.05 g (25 and 50 mg) light amber in the package of 50,100,500 and 1000.

     Storage : List B. In dry, the dark spot.

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