PIROGENAL (Pyrogenalum).

     Lipopolisaharid formed in the process of microbial life seudomonas P aeruginosa and others.

     Light Cream amorphous powder. The easily soluble in water. Solutions colourless, transparent.

     The drug has pirogennoe effect. Drug activity determined by biological and expressed in the MPD (minimum pirogennaya dose). 1 MPD is the number of substances causing intravenously with rabbits raise body temperature at 0.6 C and above.

     The nature of presents similarities with prodiogizanom. Pirogenala impact on immunological processes relatively little, but it is possible that it is also linked to interferonogennoy activity.

     Entering pirogenala, increased body temperature, there radiation, smenyayuschayasya leucocytosis, increased permeability of fabrics, including gematoentsefalicheskogo barrier, suppressing development of scar tissue, improved recovery processes in nerve tissue, etc. The preparation will be better penetration of chemotherapy substances in the home defeat.

     Applied pirogenal to promote recovery after injury and illness central and peripheral nervous systems; For resorption pathological scars, adhesions after burns, injuries, the adhesive process in the abdominal cavity in the treatment of patients suffering from infectious diseases, especially when prolonged, recurrent course.

     Pirogenal also used in some allergic diseases (bronchial asthma), psoriasis, a chronic diffuse streptodermii, scars processes in the bronchi, and epididimitah prostatitis, and some persistent Medicine (Neurodermatitises, urticaria, etc.), chronic inflammatory diseases female genitalia and other diseases .

     Pirogenal also used as an additional tool in the non-treatment of syphilis.

     Enter one intramuscularly once a day. Injections produce in a day or at long intervals (2 to 3 days). Doses to be collected individually. Initial dose is 25-50 MPD. Set the dose which causes the body temperature to rise to 37, 5-38 'C, and introduce it to stop raising the temperature, and then gradually increase the dose to 25 50 MPD. The maximum single dose for adults 1000 MPD. The course of treatment consists of 10-30 injection; Repeat if necessary. Break between courses must be at least 2 to 3 months.

     The children dose reduced in accordance with age; Start with a 5-15 MPD, gradually increasing the dose as necessary, but not exceeding 250-500 MPD. At treated 10 - 15 injection.

     In overdose pirogenala individual patients may have trembled, increased body temperature, headache, vomiting, pain in the back. These reactions are continuing normally 6 to 8 hours, after which the body temperature is reduced and the side effects disappear. In these cases, reduce the dose (of cases of severe reactions must be reported to the State Institute of Medical controlling biological products (Moscow, Sivtsev Vrazhek, 41) and the Institute of Epidemiology and Microbiology, N. F. Gamalei (Moscow. Gamaleja, 2).

     The drug can be patient with acute febrile diseases, and pregnant. Patients with hypertensive disease and diabetes medication appointed in small doses, increasing their care.

     Young children and people over 60 years of age are required to pirogenal ostorozhnootyu from small dose and gradually increasing their only good endurance drug patients.

     Product : in ampoules containing 1 ml isotonic sodium chloride solution, 100; 250; 500 or 1000 MPD.

     Storage : the potted amlulah in the dark place at a temperature of up to + 2 + 10 C.

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