KVETIAPIN (Quetiapine).

     2-[2 - (4-Dibenzo [b, f] [1,4] tiazepin-11- mud-1 piperazinil) etoksi] - ethanol fumarat.

     Synonym : Serokvel, Seroquel.

     Contact 5-NT1- serotonin, D1 and D2- dofamine, AC adrenogenital and N1- gistaminovymi receptors.

     Quickly and completely absorbed in the digestive tract, T 1 / 2 of 7 h; Under intense biotransformation, devoted mainly kidneys.

     When applied to schizophrenia productive and negative symptoms.

     Assign the inside, starting with 0,025 g (25 mg) two times in the first day and increase the dose to a single 0.05; 0.1 and 0.15 g, respectively, in 2,3 and 4 th days; Average 0.3 g daily dose (300 mg); maximum 0,75 g (750 mg).

     Possible side effects : sleep disturbance, anxiety, dry mouth, neuralgia, tachycardia, Orthostatic Hypotension, mialgiya, oppression blood, increased body temperature, lower level of thyroid hormones in the blood, rarely extrapiramidale disorder.

     The drug is contraindicated in violation of blood, severe liver and kidney diseases, diabetes, gipertireoidizme, pregnancy, breast-feeding.

     Product : pills to 0,025; 0.1 and 0.2 g (25; 100, and 200 mg N) (8, 10 and 10, respectively).

      Storage : List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines