HIFENADIN (Quifenadine)

Chemical name: alpha, alpha Difenil-3- hinuklidinmetanol (and as hydrochloride)

 

      Description: Derivative hinuklidina. The white crystalline powder odourless, bitter taste. Malorastvorim in water and alcohol.

 

      Pharmacology: Farmakologicheskoe action-antigistaminnoe, protivoallergicheskoe.

  Blocks gistaminovye H1- receptors. Activate diaminoksidazu-enzyme, inaktiviruyuschy Histamine, and reduces maintenance mediator in the tissues. Weakened spazmogennoe of histamine on bronchial smooth musculature and ulcers, reduces its hypotensive effect and influence on vascular permeability. Provides antiserotoninovoe moderate, and low mestnoanesteziruyuschee holinoliticheskoe effect.

  After receiving inside about 45% hifenadina rapidly absorbed from the digestive and found in the tissues of the body after 30 minutes. Cmax in blood plasma achieved through 1:00. The highest content hifenadina observed in the liver, a smaller number in the lungs and kidneys, the lowest in the brain (hifenadin has low lipofilnostyu poorly permeates through GEB, has expressed no negative impact on the nervous). Metabolized in the liver. Metabolites derived from the urine, bile and through the lungs. Through neadsorbirovannaya return of bowel preparation.

  The duration of 6-8 h.

 

      Application: Pollinoz, allergic rhinitis, Urticaria, Eczema, psoriasis, neyrodermit, skin itching, allergic complications associated with the use of drugs or receiving food neinfektsionno- allergic reactions to bronhospasticheskim component angionevrotichesky swelling.

 

      Contraindications: Hypersensitivity, pregnancy, breast.

 

      Restrictions on the use: Heavy cardiovascular diseases, liver and kidney disease stomach ulcers and stomach cancer.

 

      Application of pregnancy and breast feeding: When pregnancy (especially in the first trimester) is possible if the expected effect therapy exceeds the potential risk to the fetus. At the time of treatment should stop breastfeeding.

 

      Adverse actions: Suhost oral mucosa, diarrhoea phenomenon sedative effect.

 

      Networking: Raise the suction slowly absorbiruyuschihsya LS (eg antikoagulyantov indirect action kumarinov). It reinforces the negative action TSNS alcohol and psychological means.

 

      Overdose: Symptoms: drought of mucous membranes, headache, vomiting, pain in the stomach and diarrhoea phenomenon.

  Treatment: Washing stomach, receiving activated carbon, a symptomatic therapy.

 

      Dosing and Administration: inside (after eating): adults on 25-50 mg 3-4 times a day (maximum daily dose of 200 mg) for 10-20 days, if necessary, again; Children from 2 to 3 years on 5 mg 2-3 times a day, from 3 to 7 years to 10 mg 2 times a day, from 7 to 12 years on 10-15 mg 2-3 times a day, over a 12 - to 25 mg 2-3 times a day. The course of treatment-10-15 days.

 

      Precautions: Because of the high degree of sensitivity can individually weak sedative effect, so when appointing people whose work requires quick mental or motor response (drivers, etc). Should be pre-determined (by short supplies), not whether the patient after hifenadina sedative action.

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