REAFERON (Reaferonum).

     Recombinant a 2-interferon, produtsiruemy psevdomonady bacterial strain, the genetic machinery that built the gene and the human leukocyte interferon-2. Identical human leykotsitarnomu a 2-interferon.

     IFN-porous powder or porous mass of white. Mg in the water. Gigroskopichen.

     Has antivirus, ummunomodulating and antitumor activity.

     IFN applied to viral and malignant diseases.

     The drug is effective in viral hepatitis. Assign adults in the treatment of acute viral hepatitis B. The drug is most effective in early jaundiced period to 5-day illness. With advanced liver coma holestaticheskom during hepatitis medicines little effective.

     Applied IFN with viral conjunctivitis, keratokonyunktivite, keratite, uveite, and volosato- cell leukemia, chronic mieloleykoze, kidney cancer. There is also evidence of the application reaferona in adjuvant therapy of MS.

     Assign IFN intramuscularly, subkonyunktivalno and local.

     To introduce the contents of one intramuscular injectable dissolve immediately prior to use in 1 ml isotonic sodium chloride solution.

     In acute hepatitis B, enter 1000000 for IU reaferona 2 times a day for 5 to 6 days, then has 5 days to 1 IU 1 million times a day. If necessary, continue to impose on 1000000 IU 2 times a week for 2 weeks. The total dose of treatment reaferona 1500000020 000000 IU.

     In volosato- cell leukemia enter 30000006 000000 IU daily during 2 months. Supportive therapy-3000000 ED 2 times a week. At treatment-420000000 600000 0000 IU.

     In kidney cancer (stage IV) impose on IFN 3000000 IU daily for 10 days. Courses (3 - 9 and above) repeated at intervals of three weeks. Total product ranges from 90 million to 270 million IU, and more.

     In scattered sclerosis imposed on 1000000 IU 3 times daily with pyramid syndrome, and 1 to 2 times daily with mozzhechkovom. Enter for 10 days, then reduce the number of introductions : the same dose one day a week for 5 to 6 months.

     In ophthalmic practice applied in the form of IFN subkonyunktivalnyh injection and local, in the form of eye drops. For subkonyunktivalnogo introduction and instillyatsy Content 1 capsules dissolve in 5 ml isotonic sodium chloride solution.

     Subkonyunktivalno imposed in stromalnom keratite and keratoiridotsiklite to 60,000 IU in 0.3 ml every day or every other day, depending on the severity of the process. The course of treatment 15-25 injections, which are under local anaesthetic solution dikaina 0.5%. When conjunctivitis and buried in a shallow keratite konyunktivalny bag stung eyes on two drops of solution, ranging from 6 to 8 times a day, followed by 3 to 4 times daily. The course of treatment is about 2 weeks.

     In applying reaferona possible shivers, general malaise, increased body temperature, skin allergic reaction (rash, itching of the skin), leyko- and thrombocytopenia. In stark expressed side events injections cease. In the application, there are local irritation close-single hair, swelling konyunktivy.

     Contraindications : allergic diseases, pregnancy (insufficient number of observations). For patients with cardiovascular disease need hemodynamic monitoring (periodic registration EKG).

     Product : potted in ampoules.

     Storage : List B. With the temperature of + 4 + C to 10 C.

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