REZERPIN (Reserpinum). 3, 4, 5-Trimetoksibenzoat metilrezerpata.

     Reserpine is asexual, in rauvolfii plants.

     Wood (Rauwolfia; R and uwolfia ser re ntina We nth.) Multi-family bushes kutrovyh (n Arosu Asea e) is growing in the south and south-east Asia (India, Sri Lanka, Java, Malay Peninsula). Botanical description of the plant was made in the XVI century. German doctor Leonhard Rauwolf. Extracts from the leaves and roots of plants has long been used in traditional Indian medicine. Plants, especially roots, with a lot of

alkaloids (Reserpine, restsinamin, aymalin, aymalitsin, aymalinin, rauvolfin, serpin, serpagin, yohimbin etc.).

     Alkaloids rauvolfii have valuable pharmacological properties. Some of them, especially Reserpine and to a lesser extent restsinamin have a sedative and anti-hypertensive effects, other (aymalitsin, rauvolfin, serpagin, yohimbin) - adrenoliticheskoe. Aymalin has antiaritmicheskoe effect.

     Reserpine and others of the alkaloids found in R. sa ns nes Chairman Linn. , R. micranth a Noo k; R. tetr ares h in a ll L., R. h e t e r h-op from lla Roem e t Schut and other rauvolfii.

     Abroad Reserpine published under the title : Rausedil, Alserin, Crystoserpin, Escaserp, Hiposerpil, Quiescin, Raupasil, Rau-Sed, Rausedan, Rausedyl, Reserpoid, Roxinoid, Sedaraupin, Serfin, Serpasil, Serpate, Serpen, Serpiloid, Serpin, Tenserpine et al .

     White or yellow melkokristallichesky powder. The easily soluble in glacial acetic acid and chloroform, very little water, alcohol, ether.

     The main pharmacological properties rezerpina his simpatoliticheskoe effect due to the fact that under its influence rapidly available (released) catecholamines from granulyarnyh depot presinapticheskih nerve endings. Catecholamines were unleashed inaktiviruyuschemu monoaminoksidazy action that leads to a reduction in entry catecholamines in synaptic gap and reduce the impact on the adrenergic system effector peripheral organs, including adrenoretseptory blood vessels.

     Step rezerpina also includes central nervous system. Under his influence the content decreases in brain tissue neyromediatorov noradrenalina, dopamine, serotonin, as a result of its ability to disrupt transport of these substances from the cell plasma (where their biosynthesis) in the granules, where they are deposited. In plasma, they are exposed on its monoaminoksidazy become inactive (dezaminirovannye) metabolites.

     Reserpine have complex effects on the organism. In effect on the peripheral nervous system largely as a result of its antihypertensive effect and the influence of the central neurochemical processes - neurotic.

     Initially, before the emergence of modern neyrolepticheskih funds Reserpine used for the treatment of mental illness. Currently Reserpine as antipsihoticheskoe tool used rarely, mostly it is used as a tool for antihypertensive treatment of hypertension. Assign more often in combination with other means antigipertenzivnymi (Diuretics, etc.).

     Influenced rezerpina gradually lowered systolic and diastolic pressures in different forms and stages of hypertension. The best effects in the early stages of hypertension, in the absence of expressed organic changes cardiac system. Anti-hypertensive effect for a long shelf life after receiving rezerpina.

     Along with decreasing AD improving kidney function : increasing renal blood flow, increasing klubochkovaya filtering.

     There is a positive impact rezerpina of lipid and protein in patients with hypertension exchange disease and coronary atherosclerosis.

     Assign Reserpine inside a pill (after eating). Dose and duration of treatment picked individually.

     When hypertension in the early stages of appointing Reserpine usually 0.05-0.1 mg 2 to 3 times a day. In some cases, enough to continue to use drugs in these doses, in other dosage gradually increased. Typically, in order to avoid depression limited to a daily dose of 0.5 mg, but with good endurance its increase to 1 mg. If within 10 -14 days of anti-hypertensive effect will not come, drug overturned.

     On reaching effect gradually lower the dose of 0.5 to 0.2-0.1 mg per day. Treatment of small doses of (maintaining) a long-term (two courses for 3-months, if necessary 3 - 4 times a year), under the supervision of a physician.

     Applied also Reserpine with milder forms of heart failure with tachycardia (with cardiac glycosides), gipersimpatikotonii, late toxicosis pregnant. In tireotoksikozah Reserpine appointed with tireostaticheskimi substances (see Merkazolil). Sam Reserpine tireostaticheskogo do not have, but it reduces neuro disorder is ischemia pulse. Application rezerpina reduces dose antitireoidnyh drugs.

     In psychiatric and neurological practice Reserpine mostly in psychical disorders of the foundation increased AD, as well as persistent insomnia and other diseases. When treating schizophrenia Reserpine sometimes used in combination with other doses. Reserpine is also recommended for the treatment of alcoholic psychosis.

     When mental illness Reserpine take inside on the first day of 0.25 to 2 mg dose and then increase to 10 to 15 mg per day.

     In nervousness appointed in small doses, ranging from 0.25 mg 2 to 3 times a day to 0.5 mg 3 or 4 times a day.

     Higher doses for adults inside : single 0,002 grams (2 mg), daily 0.01 g (10 mg).

     Children Reserpine designate dose of 0.1 to 0.4 mg / day (2 - 4 admission), depending on age.

     In small doses Reserpine side effects usually is. In high doses, and high sensitivity can be observed hyperemia mucous membranes of eyes, skin rashes, stomach pain, diarrhoea, aetiology, weakness, dizziness, dyspnoea, nausea, vomiting, nightmares. With long-term use may parkinsonizma phenomenon. In exchange treatment in patients with mental illness can develop a sense of worry, anxiety, insomnia hard, depression. For patients with bronchial obstruction Reserpine can cause acute bronchospasm attack. Atropine relieve bronchospasm.

     In side-events should be reduced or temporarily dose rezerpina it lifted. When pain in the stomach and diarrhea designate holinoliticheskie funds. Doing extrapiramidale disorders using tsiklodol, tropatsin ANTIPARKINSONISM or other drugs.

     When taken drugs in outpatient settings should be allowed to keep and general weakness.

     Patients suffering koronarosklerozom are advised to start with small doses and both koronarorasshiryayuschie funds.

     Contraindications : heavy organic cardiovascular disease events with decompensation and expressed aetiology, nefroskleroz, cerebral sclerosis, a disease of stomach ulcer and duodenal ulcer.

     Reserpine has the ability to increase the secretion of prolactin. In an experiment on rats a linear strain, it can stimulate the development of breast cancer. Detailed clinical and experimental research into the All-cancer research center Academy of Medical Sciences (1992-Cancer Research Center, Russian Academy of Medical Sciences) have confirmed, however, failed submissions that breast cancer in humans may be influenced rezerpina.

     Method of issuance : powder; Pills to 0.0001 g (0.1 mg) and 0.00025 grams (0.25 mg).

     Storage : A powder-list, in a densely ukuporennyh banks orange glass in a cool place protected from the light, a list of B pill, in a cool place protected from the light. Reserpine and three foreign issued in the form of tablets containing 0.1 and 0.25 mg drug, and 1 ml ampoules of 0.1% and 0.25% solution (ie with 1 or 2, 5 mg of ampoules).

     Solutions appointed intramuscularly (or impose slow intravenous) for edema PNDS crises, in the form of heavy hypertension, and sometimes in heavy psychosis with phenomena occur.

     Reserpine is part of the combined number of drugs used for hypertension.

     Adelfan (A delphan) - pill containing rezerpina 0.0001 g (0.1 mg) and digidralazina 0.01 g (10 mg).

     Digidralazin similar in structure and action to apressinu (see), a peripheral vazodilatatorom.

     Applied with hypertension and 1 - 2 pills three times a day (after eating).

     Adelfan- ezidreks (A delphan-Esidrex) rezerpina contains 0.1 mg, digidralazina dihlotiazida 10 mg and 10 mg, and adelfan- ezidreks- K (A d e lphan- E sidrex K) - rezerpina 0.1 mg, digidralizina 10 mg, 10 mg and gidrohlortiazida potassium chloride 0.6 g and a Bean. Adding potassium chloride designed to prevent the possible gipokaliemii of gidrohlotiazida.

     Assign 1 / 2 - 1 tablet 1 - 2 - 3 times a day.

     Brinerdin (In rinerdin). Beans containing rezerpina 0.0001 g (0.1 mg), digidroergokristina 0.0005 g (0.5 mg), klopamida (brinaldiksa) 0,005 g (5 mg).

     Digidroergokristin is peripheral and central adrenoblokiruyuschim funds; Klopamid - saluretik.

     Applied with hypertension and symptomatic hypertension.

     Is the inside of one pills from 1 to 3 times a day (depending on the nature of the disease and the patient). The course of treatment from 10 days to several months.

     Product : Bean in a package of 30 pieces.

     Storage : List B.

     Kristepin (P r er in a st). Beans, rezerpina containing 0.1 mg, 0.5 mg and 5 mg digidroergokristina diuretika klopamida. When applied in various forms of hypertension. Is starting 1 pills a day, then as needed increasing dose to 2 - 3 pills a day for 2 to 3 admission. Supporting 1-dose pills a day or every other day.

     Neokristepin (Neocrystepin). Beans, rezerpina containing 0.1 mg, 0.58 mg digidroergokristina (mezilata) and 25 mg diuretika hlortalidona (see Oksodolin). Is one of pills a day or every other day; In more severe cases, Bean 1 2 - 3 times a day.

     Trirezid (T riresid) and Triniton (T riniton) * tablets of the same : rezerpina 0.1 mg, digidralazina sulfate (see Apressin) gidrohlortiazida 10 mg and 10 mg.

     Trirezid issued with additional content in each pill 0.35 g potassium chloride (see also Adelfan- ezidreks- K).

     Indications for use trirezida and trinitona like to kristepina etc.

     Before all these pills (except containing potassium chloride) patients should be encouraged to eat, rich potassium. Care should be taken kaliemiey.

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