RIBOFLAVIN (Riboflavinum).

     VITAMIN B 2 (Vitaminum In 2). 6, 7-Dimetil-9- (D-1- ribitil) - izoalloksazin.

     Synonyms : Beflavin, Beflavit, Betavitam, Flavaxin, Flavitol, Lactobene, Lactoflavin, Ovoflavin, Ribovin, Vitaflavine, Vitaplex B2, etc.

     Yellow-orange crystalline powder bitter taste, with low specific smell. In light fragile. Little is soluble in water and alcohol. Aqueous solutions are yellow colour and intense zheltovatozelenuyu fluorescence; Solutions pH 5 0 7 0. Sterile with 100 'C for 30 min.

     Vitamin B 2 widely distributed in plant and animal species. In humans comes primarily from meat and dairy products. Contained in yeast, dairy whey, egg protein, meat, fish, liver, peas, shell embryos and cereals. Received also synthetically.

     When the body interacts with riboflavin adenozintrifosfornoy acid to form flavin- mononukleotid and flavinadeninnukleotid. The latter are prosteticheskimi Group (kofermentami) flavinproteinov and participate in the transfer of hydrogen and regulation of redox processes. Riboflavin is participating in Carbohydrate, Protein and fat exchange; He also plays an important role in maintaining the normal functions of visual eye and in the synthesis of hemoglobin.

     With low or no content of vitamin B 2 from humans giporiboflavinoz then ariboflavinoz. In giporiboflavinoze been reduced appetite, drop weight, weakness, headache, a feeling of burning the skin, eyes mulligrubs in breach of twilight, pain in the corners of the mouth and on the lower lip. In developing the disease rifts and crust in the corners of the mouth (the so-called angular stomatitis), the language of dry, tunnelling, razviraetsya super dermatitis noso- lip folds; There refers, conjunctivitis, Blepharitis.

     Daily demand for vitamin B 2 of adult about 2, 5 mg, with heavy physical labour, about 3 mg; For children from 6 months to 1 year, 0.6 mg; 1 to 1 5 1 1 mg; 1, 5 and 2 years - 1, 2 mg; from 3 to 4 years - 1, 4 mg; from 5 to 6 years - 1, 6 mg; from 7 to 10 years - 1, 9 mg; from 11 until 13 years 2, 3 mg; boys 14-17-2, 5 mg; girls 14 to 17 years - 2, 2 mg.

     In therapeutic uses riboflavin used in hypo-and ariboflavinoze with night blindness, conjunctivitis, iritah, keratitis, corneal ulcers, cataract, in the long-term healing wounds and ulcers, common violations nutrition, radiation sickness, fatigue, bowel function violations, rich, disease Botkina , and other diseases.

     Assign riboflavin inside of powders, tablets, pills and in the form of eye drops (0.01% solution).

     Under the therapeutic dose when administered to adults is 0,005 - 0,01 g (5 - 10 mg) a day, with more severe cases, 0.01 g three times a day (over 1 - 1 5 months) . Children appoint 0,002 - 0,005 grams to 0.01 grams per day, depending on age.

     Provided kidney from the body. Once inside (or by injection), riboflavin (and riboflavin- mononukleotid) urine stains in light yellow color.

     Method of issuance : powder; 0,002 grams of pills as a preventive measure; Pills to 0,005 g and 0.01 for medicinal purposes.

     Storage : powder in a glass of orange ukuporennyh banks; Pill-in the dark spot.

     Rp. : Ta b. Vini Ribofl and 0,005 N. 50

     D.S. At one pill two times a day

     R p. : Sol. Riboflavini 0.01% 10 ml

     D.S. On 1 - 2 drops in each eye two times a day

     Riboflavin is a member of multivitamin preparations (see Geptavit, Aerovit, Kvadevit, Glutamevit, Komplivit etc.).

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