RIFAMPITSIN (Rifampicinum). 3 (4-Metil-1- piperazinil- iminomethyl) - rifamitsin SV 2.

     Semi antibiotic derivative rifamitsina (see).

     Synonyms : Benemitsin, Rifadin, Rifamor, Benemycin, Rifadin, Rifaldazin, Rifaldin, Rifamor, Rifampin, Rifoldin, Riforal, Rimactan, Ripamisin, Tubocin and others.

     The crystalline powder or brown-brick red. Almost nerastvorim in the water, little is soluble in alcohol. Sensitive to the action of light, oxygen and moisture in the air.

     Rifampicin is a broad-spectrum antibiotic. He is active against Mycobacteria tuberculosis and leprosy, a gram of (especially staphylococci) and gram (meningokokki, gonokokki) Gioacchino less active against gram of bacteria.

     Unlike rifamitsina rifampicin is more effective when administered as well as a broader spectrum antibacterial action.

     Rifampicin well absorbed from the gastrointestinal tract. The maximum concentration in the blood is achieved through 2 - 2 5 h. after the reception inside.

     When intravenous drip a maximum concentration of rifampicin there by the end of Infusion. At the level of concentration of therapeutic drug when administered intravenously, and is supported within 8 to 12 h against highly pathogenic for a period of 24 h. Rifampicin well penetrates the tissues and body fluids and is found in therapeutic concentrations in the blood exudation, sputum, content caverns bone. The highest concentration of a drug in the tissues of the liver and kidneys. Of the body's output of bile and urine.

     Resistance to rifampicin evolving rapidly. Cross sustainability with other antibiotics has not (except rifamitsina).

     The major indication for the use of a light tuberculosis and other organs.

     In addition, the drug is used in various forms of leprosy and inflammatory lung diseases and respiratory tract (bronchitis, pneumonia) caused by staphylococcus polirezistentnymi with osteomyelitis, urinary infections and psoriasis ways, acute gonorrhea and other infections caused by susceptible to rifampicin cause.

     The rapid development of resistance, rifampicin appointed in netuberkuleznyh diseases only when other antibiotics are ineffective.

     Rifampicin has virulotsidnoe effect on the rabies virus, suppresses the development rabicheskogo encephalitis; In this context it is used for the integrated treatment of rabies incubation period.

     Rifampicin take into shock (for 0.5 to 1 hour before meals) or injected drip (adults only).

     To make the solution, to throw 0.15 g rifampicin 2, 5 ml of sterile water for injection, vigorously vstryahivayut vials of powder until dissolved received solution to throw in 125 ml of 5% glucose solution. Enter a speed of 60 to 80 drops per minute.

     When treating tuberculosis average daily intake for adults inside 0.45 g 1 per day. For patients (especially the escalation) weighing 50 kg daily dose can be increased to 0.6 g. The average daily intake for children older than 3 years, 10 mg / kg (but not more than 0.45 grams per day) 1 times day. When bad Portability rifampicin daily dose can be divided into two installments.

     Intravenous introduction of rifampicin recommended severe progressive and widespread destructive forms of pulmonary tuberculosis, severe abdominal septic processes, the need to build a high concentration of drug in blood and the reception inside the preparation difficult or poorly transferred patients.

     When intravenously daily intake for adults is 0.45 grams, with a rapidly progressing form of heavy-0,6 g and become one reception. The drug intravenously injecting within 1 month. and more and moving to a reception inside and depends on the endurance drug. The total duration of rifampicin in the treatment of tuberculosis is effective and can reach 1 year.

     When treating tuberculosis rifampicin (intravenously), in patients with diabetes is recommended for every 4 to 5 g of glucose (solvent) to introduce two ED insulin.

     Monotherapy TB rifampicin often accompanied raevitiem sustainability cause of antibiotic, so it should be combined with other anti means (streptomycin, isoniazid, ethambutol, etc.), which retained the sensitivity of Mycobacteria tuberculosis.

     When rifampicin leprosy used for the following schemes : a) the daily dose of 0.3 - 0.45 g, introducing one reception; When bad Portability-2 admission. The duration of treatment 3 to 6 months. Courses repeated at intervals of 1 month; B), while combination therapy appoint daily dose of 0.45 g 2 - 3 admission for 2 to 3 weeks at intervals of 2 to 3 months. within 1 year to 2 years or to the same dose of 2 to 3 times in one week for 6 months.

     Treatment with a comprehensive means ltd.

     When infection netuberkuleznoy Nature, adults take rifampicin inside of 0.45 - 0.9 grams per day, and children under 8 to 10 mg / kg in the 2 - 3 admission. Intravenous introduce adults in a daily dose of 0.3 - 0.9 g (2 - 3 introduction). Enter within 7 to 10 days. As to go to the reception of the drug inside.

     In acute gonorrhea appointed interior dose of 0.9 grams per day once or within 1 to 2 days.

     To prevent rabies, adults are inside of 0.45 - 0.6 grams per day, with heavy injuries (bite in the face, head, hands) for the 0.9 g / day; Children under 12 years - to 8-10 mg / kg. The daily dose divided into 2 - 3 admission. The duration of 5 to 7 days. Treatment for both active immunization.

     Treatment rifampicin should be under close medical supervision. Possible allergic reactions (of varying degrees), although they are relatively rare; Moreover, diarrhoeal phenomenon dysfunction of the liver and pancreas. With a long reception drug and must be studied and a liver function blood tests (for the opportunity to the development of radiation).

     With rapid intravenous AD may decline, as a long-flebit develop.

     The drug reduces the activity of anti-proximity, oral gipoglikemicheskih of drugs lapidary. In simultaneous admission and anti rifampicin, with the lifting of the last dose of anti - should be reduced.

     The drug is bright brownish red. It stains (especially at the beginning of treatment), urine, sputum, lachrymal fluid in oranzhevokrasnovaty color.

     Rifampicin contraindications infants, pregnant with jaundice, kidney disease by lowering excretory functions, hepatitis and heightened sensitivity to the drug.

     Intravenous introduction contraindicated with cardiopulmonary diseases and flebite.

     Method of issuance : capsules of 0.05 and 0.15 g in a package of 10 to 20 or 30 capsules; In ampoules of 0.15 grams of porous brick or brown-red (pro injectionibus Rifampicinum 0.15) in the package of 10 vials.

     Storage : List B. In dry, the dark place at room temperature.

     The literature describes the combination drug rifametoprim capsules containing 0.15 g rifampicin and 0.04 g (40 mg) trimethoprim. Adding trimethoprim (inhibitor digidrofolatreduktazy-see Baktrim) increases antibacterial effectiveness. The drug has a wide range of activity. Assign inside a rate 0.6 - 0.9 g / day (2 - 3 admission) in the 5 - 8 (12) days.

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