SALAZOPIRIDAZIN (Salazopyridazinum). 5 - (para-[N - (3-Metoksipiridazinil-6) - sulfamido] - fenilazo) - salicylic acid.

     Synonyms : Salazodin, Salazodin.

     Melkokristallichesky powder orange.

     Salazopiridazin almost nerastvorim water malorastvorim in alcohol, dilute solution of caustic soda.

     By building and the nature of close to salazosulfapiridinu. Represents product sulfapiridazina compounds and salicylic acid. In the body disintegrates at sulfapiridazin and 5-aminosalitsilovuyu acid (see Mesalazin), have antibacterial and anti-inflammatory effect. Like salazosulfapiridinu (sulfalazinu) has immunokorrigiruyuschuyu activity.

     Salazopiridazin more active (in a smaller dose) than salazosulfapiridin.

     Applied salazopiridazin for patients nonspecific ulcerative colitis, as well as diseases which occur in autoimmune violations, including the base in the treatment of rheumatoid arthritis.

     In non-ulcerative colitis designate salazopiridazin adults inside (after eating) tablets to 0.5 g four times a day for 3 to 4 weeks. If during this period is therapeutic effect, the daily dose reduced by 1, G-1, 5 g (0.5 g 2 - 3 times a day) and continue treatment for another 2 to 3 weeks. In the absence improves, drug stop. Patients with mild forms of the disease designate product first in a daily dose of 1, 5 g, in the absence of the effect of increasing the dose of 2 g per day.

     Children aged 3 to 5 years salazopiridazin designate doses from 0.5 g / day (2 - 3 admission). If no effect within 2 weeks. drug cancel, and if therapeutic effect continue treatment at the dose for 5 to 7 days, then reduce the dose of 2 times, and continue to treat an additional 2 weeks. In the case of clinical remission daily dose reduced by half again and pass it to the 40-50-th day, as of the beginning of treatment.

     For children aged 5 to 7 years from the designated product 0,75-1, 0 grams a day, from 7 to 15 years - to-dose 1, O-1, 2 - 1, 5 g per day. Treatment and lower doses to the same pattern as that of the children from 3 to 5 years.

     Application salazopiridazina combined with the general methods of treatment and diet recommended in non yazvennem Colitis.

     Salazopiridazin can also be applied to non-ulcerative colitis and Crohn disease rectally as suspensions and candles.

     Suspension salazopiridazina 5% (Suspensio Salazopyridazini 5%). Contains salazopiridazin, Rembrandt-80, benzyl alcohol and alcohol polyvinylalcohol. Diluted after vzbaltyvaniya is suspended orange, which is then captured.

     Rectal applied for a (straight defeat and sigmovidnoy gut, in the period of pre - and post subtotalnoy kolektomii in bad Portability preparation in the form of tablets). Suspension slightly and have imposed a enema in the rectum or colon cult to 20-40 ml 1 - 2 times a day. Children are 10 to 20 ml (depending on age). Rectal introduction can be combined with the admission of the drug inside.

     Candles used rectally. In the acute phase of illness appoint one candle 2 to 4 times a day over a period of 2 weeks to 3 months. The duration of the course depends on the effectiveness of drug treatment and endurance. The maximum daily dose of four candles (2 g). You can take salazopiridazin tablets (not exceeding the total daily dose of 3 g), and other tools for the treatment of non-ulcerative colitis.

     To prevent recurrence appoint 1 - 2 candle per night for 2 - 3 months.

     Dose scheme and the appointment of drug and other forms of ulcer colitis with the same magnitude as that of a non-ulcerative colitis.

     When taken tablets salazopiridazina inside the same possible adverse reactions in the application and sulfanilamidov salitsilatov : allergic phenomena, radiation, diarrhoeal disorders, sometimes slight reductions in hemoglobin. In such cases, the dose should be reduced or eliminated medication. After a suspension can feel pain in the rectum and herbs for hair, especially with the rapid introduction. Using salazopiridazina in candlelight may feel pain and burning in the rectum, sometimes rising chair. When expressed in Rectal pain introduction salazopiridazina in candlelight, to designate drug rectally as a 5% suspension and tablets inside.

     The drug is contraindicated if MEPhI history of allergic reactions in the treatment sulfanilamidami and musk.

     Method of issuance : pills to 0.5 g in a package of 50 pieces; 5% suspension in bottles of 250 ml; Candles (brown) to 0.5 g in a package of 10 pieces.

     Storage : List B. In the dark place at room temperature.

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