SARKOLIZIN (Sarcolysinum).

     D, L-a-Amino-b- [para-bis - (b-chloro - ethyl) - aminofenil] - propionic acid hydrochloride.

     Synonyms : Racemelphalanum, Sarcoclorin (Foreign drug Melphalan is left isomer, the sarkolizinu [L-parabis- (Chandler chloroethyl) - aminofenilalamin]).

     The white or slightly yellow powder. The easily soluble in hot water, soluble in acid and alkali divorced.

     Sarkolizin derives bis - (b-chloroethyl) - amine and amino acid phenylalanine. Like other drugs of this type, sarkolizin has alkiliruyuschimi properties and stifles development giperplazirovannyh tissue.

     Applied to treat seminomy testis (especially if the cancer), retikulosarkomy, angioendoteliomy malignant neoplasms Ewing, mielomnoy disease.

     In combination with kolhaminom (see) sarkolizin sometimes used when oesophagus and stomach cancer.

     Diluted appointed interior (after eating) and intravenously, is also included in this set.

     Producing for admission into tablets of 0.01 g (10 mg), injection-dry in sealed bottles containing 0.02 and 0.04 g (20 and 40 mg) drug. For the solution imposed in a bottle 10-20 ml isotonic sodium chloride solution; To accelerate the dissolving liquid fuel in the water up to 60 to 70 C.

     Inside or intravenous drug nominated once a week. Under the dose for an adult weighing 60 to 70 kilograms of 40-50 mg; For patients weighing 50 kg or less, the rate of 0.5-0.7 mg / kg. In the first two installments are 50 mg and then to 30 mg. Children also appoint a rate of 0.5-0.7 mg / kg.

     The course of treatment continues 4 to 7 weeks. In metastasized tumors in seroznye bags with vypotom in the chest or abdominal cavity can be injected solution sarkolizina in cavities.

     In the abdominal cavity input from 40 to 100 mg dissolved in 20 to 50 ml isotonic sodium chloride solution, one day a week; In fresh cavity-20-80 mg dissolved in 10 ml - 20 isotonic sodium chloride solution, as every 1 week.

     Before the introduction of the solution in the cavity sarkolizina remove exudation, then enter anesthesia for 60 to 70 ml of 1% solution of novocaine, which is not removing the trocar from the abdomen or chest cavity of a needle, attach a patient lying position, and after 10 minutes introducing svezheprigotovlenny sarkolizina solution. At treatment usually 4 to 5 injections.

     Often, after 2 to 3 injections are resorption or decrease exudation; Injection; But still. Enter solution sarkolizina through needle diameter 0.3 - 0.5 ml; Prior (10 min) to impose 100-120 ml of 1% solution of novocaine. Total of course apply 0,2 - 0,16 g (160-200 mg) sarkolizina.

     Sarkolizin can be used for regionarnoy chemotherapy; When perfuziyah tumors limbs using extracorporeal circulation using drug dose 25 to 40 mg per 1 cm tissue perfuziruemoy area.

     Sarkolizin relatively rapid effect on tumor : therapeutic effect is usually after 2 - 3 introductions single doses (40 and 30 mg); If, after receiving 100-150 mg effect no further use of the drug found it impractical because of the insensitivity to it that the tumor.

     In applying sarkolizina oppression there will be fewer blood cells, particularly neutrophiles. In the treatment, care must be taken pictures of blood. Drug Application drop with a decrease in leukocyte count in the blood up to 3, 5-x 3 / l, and expressed thrombocytopenia [below 100 x 10 / l). At the end of treatment to determine the number of cells in the blood of each of sarkolizina.

     After the introduction sarkolizina leukocyte numbers may continue to fall further during the 1 - 2 weeks. If necessary, resort to blood transfusion (1 to 2 times per week for 100-125 ml).

     When a drug overdose and intense radiation (2 ? 10 9 / L and below), and thrombocytopenia stoichiometric could experience increased body temperature, disease, the symptoms of hemorrhagic diathesis. To prevent infection should be applied in such cases, penicillin, blood transfusion, and impose leykotsitnuyu trombotsitnuyu mass; The symptoms agranulotsitoza designate sodium nukleinat intramuscularly, as well as inside pentoksil, stronger.

     When in the process of re-treatment of nausea and vomiting nominated for edema for 1 hour before sarkolizina aminazin (0,025 grams inside), or other antiemetics etaperavin funds.

     Entering sarkolizina in cavities can be pain, nausea, vomiting; These events usually take place spontaneously. To prevent these complications should be before sarkolizina produce local anesthesia pleura (or cut).

     Sarkolizin contraindicated in terminal stages of illness, with cachexia expressed anemia, radiation (less than 4 x 109 / L), thrombocytopenia (below 150 x 10 / l), heavy defeat liver, kidney and cardiac system.

     If someone made Radiation Therapy, the sarkolizin apply no earlier than one month after the end of treatment; Preparation appointed in these cases in small doses.

     Method of production : tablets reception inside to 0.01 grams in a package of 25 pieces; Powder in vials of 0.02 and 0.04 g preparations for injecting fluids.

     Storage : A. In a list ukuporennoy package in a dry, cool place.

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