SKOPOLAMIN (Scopolaminum).

     Alkaloid contained together with atropine in Blue, Belem, dope, skopolii.

     Apply a skopolamina hydrobromide (S Soro l and mini hydrobromidum).

     Synonyms: Scopolaminum hydrobromicum, Hyoscini hydrobromidum.

     Beztsvetnye transparent crystals or a white crystalline powder. Easy soluble in water (1:3), soluble in alcohol (1:17). In order to stabilize the solutions for injection adds hydrochloric acid solution to pH 2, 8, 3, 0. Sterilize at + 100 30 min.

     Scopolamine chemically similar to atropine: a complex air Skopina and tropovoy acid. Close to the effect of atropine on the peripheral holinoreaktivnye system. Like atropine is expanding inside, paralysis of accommodation, increasing cardiac cuts, relaxation of smooth muscles reducing secretion and port digestive glands.

     Assists also central holinoliticheskoe effect. Usually causes sedative effect: reducing motor activity, could have widespread effects. Characteristic properties skopolamina is due to leave.

     Scopolamine is sometimes used in psychiatric practice as uspokaivaschego means, for the treatment of neurological - VGA, in the surgical practice with analgesics (morphine, promedol) to prepare for anaesthesia, sometimes as a means of calming protivorvotnoe and in sea and air sickness (mostly for the goal appoint pill "Aeron"), as well as iritah, iridotsiklitah and diagnostic target for rasshiireniya pupil instead of atropine.

     Contraindications are the same as in the appointment of atropine. Consideration must be given very wide differences in individual susceptibility to skopolaminu: relatively normal doses are often not calm and agitation, hallucinations and other side effects.

     Assign Scopolamine inside (usually in solutions and under the skin of single-dose 0.00025 0.0005 g (0.25 - 0.5 mg) or 0.5 to 1 ml 0.05% solution. In practice Eye (for expansion iris and paralysis of accommodation) use 25% aqueous solution (1 to 2 drops in the eye two times a day) or 0.25% ointment

     Higher doses for adults inside and under the skin: single 0.0005 g daily 0.0015 g.

     Method of issuance: powder; 0.05% solution of 1 ml ampoule.

     In ophthalmic practice, along with 0.25% aqueous solution of prolonged drug-use solution skopolamina hydrobromide 0.25% from Methylcellulose (S Solutio Soro lamini hidrobromidi 0.25% cum thylcelluloso Me). Discoloured transparent or slightly opalestsiruyuschaya fluid (pH 4, 5, 6, 5) in vials of 5 and 10 ml.

     Storage: A. In a list ukuporennoy packaging in sheltered from the world scene.

     R p. : S Contracting Sc op olamini hydrobromidi 0,05% 1 ml

     D.t.d. N. in ampull 6.

     D.S. At 0.5 to 1 ml under the skin

     Rp. : Scopolamini hydrocarbomidi 0.0025

     P r of 0.1 m e doli

     E ph e drini hydrochloridi 0,125 ml

     Q. A p r to inject. 5 ml

     M. Steril. !

     D.S. At 1 ml under the skin or intramuscularly as ordnance bolivayuschee with injuries; For induction anaesthesia

     Rp. : Sol. Scopolamini hydrobromidi 0.25% 10 ml

     D.S. Eye drops. On 1 - 2 - 3 drops four times a day (at iridotsiklite)

     P r h e and m and n and is not allowed admission into such concentration of the solution and the introduction of its skin.

     Pills "Aeron" (Ta bulettae "A on the num er). Composition: skopolamina kamfornokislogo 0.0001 g and giostsiamina kamfornokislogo 0.0004 g.

     Effects tablets with features farmakodinamiki skopolamina and giostsiamina.

     Pills "Aeron" used for the prevention and treatment of sea and air sickness, as well as to prevent attacks and kupirovaniya disease Menera [see also Dimengid p AT (Dedalon)]. They are sometimes used to reduce slize- and slyunootdeleniya with plastic operations in the face and operations in the upper respiratory tract. With air and sea sickness pills designate inside: pure 30-60 minutes before departure are 1 - 2 pills, but in the future, if necessary, at 6 h another pill. If you do not use pure travel sickness pill, it is the first sign of illness (nausea, dizziness, headache), take 1 - 2 pills, then give one tablet two times a day.

     Higher doses for adults: single pill 2, 4 pills daily.

     In rare cases, hard vomiting can be appointed instead aerona candles containing a kamfornokislogo skopolamina giostsiamina and how many in one tablet aerona.

     When illness Menera appoint one tablet 2 to 3 times a day. When surgical intervention on the face for 20 to 30 minutes before the surgery immediately appoint two tablets after operations on February 1 pill twice a day in the first two days.

     In applying aerona possible thirst, drought in the mouth and throat. To facilitate this state shall appoint, and drinking caffeine. Tablets can appoint glaucoma patients.

     Form release: 0.0005 grams of tablets in a package of 10 pieces.

     Storage: List B.

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