SEROTONINA ADIPINAT (Serotonini adipinas).

     For use in medical practice serotonin are synthetic means. 3 and overseas appears as kreatinin- sulfate, in our country, in the form adipinata.

     Synonyms kreatinin- serotonin sulfate: Anthemovister, Enteramin, Thrombocytin, Thrombotonin.

     Serotonin adipate is white or white with kremovatym white crystalline powder. Soluble in water, it is difficult to alcohol.

     By pharmacological properties of serotonin adipate no different from kreatinin- serotonin sulfate, but adipate more pillars and better soluble in water.

     Basically serotonin antigemorragicheskogo used as a tool. The effect associated with peripheral sosudosuzhivayuschim actions, the ability to increase the aggregation of platelets and bleeding short time.

     Apply serotonin adipate to treat hemorrhagic syndrome in various pathological conditions, including disease Verlgofa, gipoi aplastic anemia, trombastenii, haemorrhagic vaskulite, haemorrhagic syndrome after treatment cytotoxic means, in malignant tumors and other diseases. Serotonin increases capillary resistance and reduce the length of bleeding.

     Enter intravenously or intramuscularly. When expressed bleeding started with intravenous and reduce bleeding move on intramuscular injection.

     Initial dose-0,005 grams (5 mg); In the absence of side effects increase the dose to 0.01 g.

     For intravenous infusions razvodyat product (5 - 10 mg) in the 100-150 ml isotonic sodium chloride solution (5 - or 10 ml isotonic sodium chloride solution, which then razvodyat 100-150 ml of 5% glucose solution, plasma preserved blood) and enter kapelno (no more than 30 drops per minute).

     For intramuscular injection, 5 - 10 mg razvodyat in 5 ml of 0.5% solution of Novocaine; Enter two times a day at intervals of not less than 4 hours

     Daily dose to the adult 0,015 - 0,02 g (15 - 20 mg). The course of treatment an average of 10 days.

     It should be noted that the rapid introduction of veins and the introduction of serotonin in these small doses of liquid can cause pain during vein, abdominal pain, unpleasant feelings in the heart, increasing blood pressure, gravity in the head, difficulty breathing, vomiting, diarrhea , reducing diureza. Usually these reactions take place smoothly. When expressed adverse events, and encourages the use protivogistaminnyh protivoallergicheskih drugs. In vnutrimyshechnom a possible pain at the injection site.

     The product contraindications with acute and chronic glomerulonefrite, chronic argued, kidney disease, accompanied anuriey (serotonin is reduced kidney and vascular has antidiureticheskoe effect), with hypertensive disease stage II-III, acute thrombosis, Kvinke swelling, bronchial asthma and diseases, accompanied by increases youngest blood.

     Method of issuance: powder; 1% solution in the ampoule.

     Storage: List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines