SIBAZON (Sibazonum). 7-Chloro-2, 3-digidro-1- metil-5- phenyl-1 H-1, 4-benzodiazepin-2- it.

      Synonyms: Apaurin, Bensedin, Diazepam, Relanium, Seduksen, Ansiolin, Apaurin, Apozepam, Atilen, Bensedin, Diapam, Diazepam, Eridan, Lembrol, Pacitrian, Quetinil, Relanium, Saromet, Seduxen, Serenamin, Serensin, Sonacon, Stesolin, Ushamir, Valitran, Valium, Vatran, Vival, etc.

      White or white with a yellowish sheen weak melkokristallichesky powder. Almost nerastvorim in water, soluble in alcohol difficult.

      Sibazon (diazepam) is a major benzodiazapine tranquilizers, widely used in medical practice.

      The drug has a sedative effect, removes the emotional stress, reduce anxiety, fear, anxiety. Has miorelaksantny and protivosudorozhny effect. To enhance hypnotics, narcotics, neyrolepticheskih, analgeticheskih drugs, alcohol.

      The drug and its major metabolites derived mainly from urine.

      Sibazon appointed in various diseases neuro-psychiatric: nervousness, Psychopathy as well as TV and psihopatopodobnyh state with schizophrenia, organic brain damage, including cerebrovascular diseases, with somatic disease, accompanied by signs of emotional stress, anxiety, fear, increased irritability, senestoipohondricheskimi, obsessions and anxiety disorders, and sleep disorders. Used also for edema psychomotor stimulation and disturbing azhitatsii with these diseases.

      In child mental practice sibazon appointed to neurotic and client states, along with the above-mentioned phenomena, as well as headaches, minor, mood and behavior disorders.

      Sibazon used in the treatment of epilepsy for epileptic convulsions, mental equivalents for edema epileptic status. In connection with miorelaksiruyuschim of drug use when different spastic state.

      In combination with other drugs to treat designate sibazon abstinence syndrome in alcoholism.

      In practice anaesthetics used for the preparation of pre patients.

      In DERMA practice in zudyaschih Medicine.

      The drug reduces the secretion of gastric juice night, which may play an important role in his appointment as a means of calming and sleeping pills to patients with stomach ulcers; Also antiaritmicheskoe effect.

      Applied sibazon inside, intravenously or intramuscularly.

      When administered to designate drug adults from the dose-0, 0025 0.005 g (2, 5, 5 mg), 1 to 2 times a day and then gradually increase it. Usually single dose for adults is 0,005 - 0,01 g (5 - 10 mg). In some instances (the increased anxiety, fear, anxiety), a single dose can be increased to 0.02 g (20 mg). When treating a patient and careful clinical observation of daily intake of up to 0,045 g (45 mg). If outpatient treatment is not advisable to appoint more than 0,025 g (25 mg) a day.

      The maximum daily doses of 0.06 g (60 mg). Daily dose treatment given in 2 - 3 admission.

      Weakened and the elderly to take medication in small doses (0.0025 g = 1 / 2 g 2 - 1 pill twice a day).

      In sleep disorders adults appoint one-two tablets at night.

      Children sibazon appointed interior in the following single dose: aged 1 to 3 years - 0,001 grams (1 mg), from 3 to 7 years - 0,002 grams (2 mg), 7 years and older-0003 - 0, 005 grams (3 to 5 mg). DSA doses up to 0,002 g (2 mg), 0,006 g (6 mg) and 0,008 - 0,01 g (8-10 mg).

      Older children may need to increase the daily dose of up to 0,014-0,016 grams (14 - 16 mg).

      Cancel sibazona should be held by gradually lowering doses. Because of the possible development of psychological dependence continuous duration of treatment should not exceed two months. Before reconnecting course of treatment interruption of at least three weeks.

      Intravenous (drip or struyno) and intramuscular injection drug introduce adults mostly in cases involving mental institution, convulsions, and edema epileptic status, the treatment of acute anxiety-anxiety, depression, anxiety, including alcoholic psychosis and abstinence. The average single dose is 10 mg (2 ml solution of 0,5%), average daily mg- 30. Maximum dose: single 30 mg, 70 mg daily.

      Sedate effects within minutes after intravenous and after 30 to 40 minutes after intramuscular introduction sibazona, therapeutic effect through 3-10 days. After withdrawing severity of the disease sibazon appointed interior.

      When epileptic status sibazon slowly injected dose of 10 to 40 mg. You can, if necessary, repeated intravenous or intramuscular introduction of a 3 to 4 hour (3 to 4 times). The best effects observed in early sibazona appointment in the first three hours after a status report submitted in the form of dwarfism.

      Sibazon (diazepam) is used for sedation and ataralgezii with analgetikami and other neurotropic medications.

      Possible complications, contraindications and precautions are basically the same as for hlozepida. When intravenous solution sibazona could experience a local inflammatory processes, and therefore advised to change their place of the drug.

      Solution sibazona there should be a syringe with other drugs to avoid falling sludge.

      Method of issuance: pills to 0,005 grams (5 mg) white or white with weak yellowish sheen colors in a package of 20 pieces, as well as tablets for children to 0,001 and 0,002 grams (T abulettae Sibazoni obductae 0 , 001 aut 0, 002 pro infantibus) orange or yellow in a package of 20 pieces in orange glass banks: 0.5% solution in ampoules (Solutio Sibazoni pro injectionibus 0.5%) and 2 ml pack of 10 vials.

      Storage: List B. In the dark spot (capsules stored at a temperature not exceeding 5 + S).

      Some foreign firms diazepam (under various names), not only in the form of tablets and solutions for injection, but in the form Suppositories (5 mg of the drug) and solutions for the reception inside (2 mg in 1 ml in 100 ml bottles ).

      Diazepam is part of the preparation reladorm sleeping pills (see Tsiklobarbital).

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