SIBUTRAMIN (Sibutramine).

     (±)-( Hlorfenil n)? - izobutil-N, N-dimetiltsiklobutanmetilamina hydrochloride.

     Synonym: Meridia, Meridia.

     According to the chemical structure is similar to fluoxetin and like it has antidepressant effects. As fluoxetin, is an active inhibitor reverse takeover neyronalnogo serotonin. However actively inhibited reverse takeover noradrenalina. Abroad used as antidepressant. At the same time, studies abroad, and in some hospitals Russia indicate that sibutramine has expressed anoreksigennoy activity. A significant portion of patients (including those suffering from diabetes), receiving his amidst gipokaloriynoy diet, decreased weight (over 3 months) of 5-10%.

     Assign the interior of 0,005 grams (5 mg) 2-3 times a day.

     Usually sibutramine moved well. Despite inhibition capture noradrenalina expressed simpatomimeticheskogo (and the hypertension) of it is not (monitor blood pressure, but should be!) ; Possible hardware, insomnia, excessive loss of appetite.

     Form release: capsules of 0.01 and 0.015 g (10 and 15 mg).

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