SOLYUSULFON (Solusulfonum).

     Tetrasodium salt 4 4'- di - (3-phenyl-1, 3-disulfopropilamino) - difenilsulfona.

     Synonyms : Cimedone, Novotrone, Solapsone, Solasulfone, Sulfetron, Sulphedrone, Sulphonazine and others.

     White or yellow amorphous powder. Very easily soluble in water, virtually nerastvorim of alcohol.

     Applied to treat leprosy. I believe that the active substance is diaminodifenilsulfon resulting from the hydrolysis solyusulfona in the body.

     Enter a 50% aqueous solution intramuscularly. Injections make two trips a week. Initial single-dose 0.5 ml. In the future, it gradually increased to 0.5 ml, bringing the end of the 6 th week to 3 ml. From 7 th week imposed on 3, 5 ml for 6 months (50 injections), and then make a break for 1 - 1, 5 months. Treatment long.

     Dose for children age reduces respectively. Enter a 25% solution.

     To accelerate healing ulcers, solyusulfon also used locally in a 10% solution or masi.

     Possible side effects and contraindications are the same as for diafenilsulfona.

     Product : powder.

     Storage : List B. In dry, the dark spot.

     Solutions for injection are as follows : 50 g solyusulfona dissolve in 60 ml hot sterile water for injection; After complete dissolution cool and add sterile water for injection to 100 ml, razmeshivayut and filtered through a paper filter.

     Filtered solution should be absolutely transparent. Solution in the autoclave to sterilize + 115 C for 30 min; More than 500 ml of sterile for a period of 45 minutes; A larger amount of phenol solution can be added at the rate of 0.5%. Solutions remain in hermetically ukuporennymh receptacles in the dark spot. Solutions fit in a few days after manufacture.

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