SPIROBROMIN (Spirobrominum).

     N, N-bis - (b-Brompropionil) - N ', N "- dispiropiperaziniya dichloride.

     Synonyms : Dibrospidy chloride, Dibrospidii chloridum.

     White or almost white crystalline powder; Slightly soluble in water. almost nerastvorim of alcohol.

     On chemical structure has similarities with prospidinom.

     Applied with acute leukaemia (mostly in combination with other chemotherapy therapy means), in malignant lymphoma, cancer of the larynx, skin retikulezah and several other oncology. It may be used in combination with radiation therapy and operational intervention.

     Available in dried form spirobromina injection of 0.1 (0.1 Spirobrominum lyophilisatum pro injectionibus) - white, or almost white mass or powder. Enter intravenously or intramuscularly. Solutions are immediately before the introduction of isotonic sodium chloride solution.

     In acute leukaemia used in combination with tsiklofosfanom, karminomitsinom, vincristine therapy or other drugs. Dose 200800 mg / day (average of 500 mg / day). If the daily dose is 500 mg, once imposed; In high doses, introducing two reception in equal doses. The course of treatment 7-14 days. Perform at least two courses of 10 days interval.

     In malignant lymphoma, cancer of the larynx, skin retikulezah appoint 500 mg daily for 10 to 30 days. In clinical effect to repeat courses through 1 5-2 months.

     In applying the drug may parestezii (in person, etc.). When expressed parestezii reduce the dose or preparation overturned. You may radiation, thrombocytopenia, pain in the heart.

     The drug is contraindicated in the terminal stages of illness, expressed in the liver diseases, kidney, cardiovascular system, as expressed by radiation and thrombocytopenia.

     Product : The capacity of 5 ml ampoules containing 0.1 g of the drug.

     Storage : List A. In the dark spot.

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