SIDNOKARB (Sydnocarbum).

     N-Fenilkarbamoil-3- (b-fenilizopropil) - sidnonimin.

     Synonyms : Mesocarb, Mesocarbum.

     White to yellowish greenish white crystalline powder. Almost nerastvorim in water, soluble in alcohol difficult.

     Sidnokarb-original domestic Psychostimulants. On chemical structure, it has some similarities with fenaminom because it fenilizopropilny Radical; However, it differs significantly from fenamina that is not free amino; Nitrogen atom of the amino nitrogen from fenamina, is a part sidnokarba heterocyclic system sidnonimina, replacement of iminogruppe fenilkarbamoilnym radical.

     On chemical structure similar to sidnokarb sidnofenu (see).

     Sidnokarb is currently the main psihostimulyatorom used in the domestic medical practice. Compared with fenaminom considerably less toxic and has expressed peripheral simpatomimeticheskogo influence. His incentive to develop gradually (no dramatic start activating effect), compared with fenaminom it more long-term and is not accompanied by euphoria and motor excitation. Such effect is not accompanied by palpitations, a sharp rise in blood pressure and other peripheral simpatomimeticheskimi effects. In the period aftereffect no overall weakness and wasting.

     On neyrohimicheskomu the operation sidnokarb different from fenamina. Experimental data show that sidnokarb stronger effect on noradrenergicheskie than dofaminergicheskie, the structure of the brain, while fenamin is stronger dofaminergicheskim action. It is possible that sidnokarb also differs from fenamina activity on the release of catecholamines from neyronalnyh depot. It is believed that these neurochemical features of sidnokarba to some extent determines differences in clinical effectiveness and transferability sidnokarba than fenaminom.

     Sidnokarb applied to different types of Pichinde underway with inhibition, weakness, apathy, loss of efficiency, ipohondrichnostyu, elevated mood. It is effective in treating stuporoznyh, substuporoznyh and apatoabulicheskih states in meningitic and nevrastenicheskih disorder in patients who undergo an intoxication infection and brain injury; When vyalotekushey schizophrenia dominated Pichinde disorders (in the absence of productive symptomatic). Sidnokarb can also be applied to artificial exacerbation of schizophrenia to overcome resistance to the therapy psychotropic drugs.

     Sidnokarb an effective way of kupiruyuschim asthenic phenomena arising from the application neyrolepticheskih drugs. It is an effective corrector, which reduces or withdraws side effects (miorelaksatsiyu, MG) caused some tranquilizers benzodiazepinovogo (fenazepamom etc.); While it does not diminish trankviliziruyuschy effect. Optimal dose ratio and fenazepama sidnokarba is 1:1, 1:2 or 25, 5 (at higher doses sidnokarba 1:5 may be a night of sleep disorders). Assign sidnokarb can simultaneously with fenazepamom or have evolved side events. Preliminary application sidnokarba less effectively.

     Sidnokarb can be recommended for patients with alcoholism dominated in clinical picture sunk, weakness, and the reaction between astenonevroticheskih <<removal of alcohol>> with alcohol adinamicheskoy with depression symptoms. Given sidnokarba stimulating effects, it can be used to reduce the phenomenon of abstinence.

     Sidnokarb also effective in children with delayed mental development in adinamii, aspontannosti, organic diseases, central nervous system, the predominant clinical picture of weakness, delayed, fatigue. There is considerable effectiveness in treating sidnokarba giperdinamicheskogo syndrome in infants.

     The drug is also effective in the night incontinence of urine.

     Sidnokarb well absorbed by ingestion. Assign it as a pill 1 to 2 times a day in the morning (before eating). Dose choose individually. Initial dose is normally 0,005 grams (5 mg); If necessary, gradually raise the dose in adults up to 0,015 - 0,025 -0.05 g per day.

     Supported dose-0,005 - 0.01 grams per day. Patients lyutsidnoy katatoniey drug dose can be increased to 0,125, 0,15 g (125-150 mg) a day.

     Children weakened sick and the elderly drug appointed in small doses (daily dose 0,0025 - 0,005 grams 2 admission).

     Higher doses of the adult inside : single 0,075 grams daily 0.15 g.

     Sidnokarb usually well. When possible overdose irritability, anxiety. Perhaps growing delirium and hallucinations in patients with previously available productive psychopathologically symptoms. Sometimes there decrease appetite. Perhaps moderate rise in blood pressure. Adverse events were decreased dose or suspend admission preparation.

     In connection with high efficiency and good portability sidnokarb almost completely replaced the fenamin.

     Sidnokarb should not be brought to appoint a sick and weak events irritant. Prudence requires dramatically expressed in atherosclerosis and severe forms of hypertension. In order to sleep at night should not take medication during the evening hours.

     Given the strong impetus to the sidnokarba, it should be appointed strictly on the evidence, not too long.

     Product : pills to 0,005 grams (5 mg); 0.01 g (10 mg) and 0,025 g (25 mg).

     Storage : List A. In the dark spot.

     Sidnogluton (Sydnoglutonum) is a combination drug containing 0,025 grams of sidnokarba and glutamic acid 0.1 g (see Glutamic acid).

     Glutamic acid as mediatornaya amino acids, enabling central neyromediatornye processes increases sidnokarba stimulating effect.

     Assign an adult inside to enhance physical and mental fitness.

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