TAMOKSIFEN (Tamoxifenum). 1-[para-[2 - (Dimetilamino) - etoksi] - phenyl] - p t Hans-1, 2-butene difenil-1-.

     Available in the form of citrate.

     Synonyms : Zitazonium, Citofen, Noltam, Nolvadex, Tamaxin, Tamofen, Tamoplex, Tamoxifen citrate, Valodex, Zitazonium and others.

     The structure has similarities with hlortrianizenom klomifentsitratom and (see).

     The drug is seen as one of the main contemporary antiestrogenov.

     Antiestrogennogo mechanism of tamoxifen and other antiestrogenov explain their competitive ability to communicate with oestrogen receptor in organah- target and thus hinder education estrogenretseptornogo complex with the endogenous ligand-17-b-seconds.

     As anticancer tool used tamoxifen in breast cancer among women (postmenopauzalnom period), and endometrium cancer, as well as in anovulyatornom infertility.

     Assign inwards in the form of tablets, with breast cancer are 20-40-1 mg 2 times a day; In endometrium cancer-20 - 30-1 mg 2 times a day; Anovulyatornom with infertility-10 mg, 2 times a day during the four days, starting from 2-day menstruation. In subsequent four-day cycles, you can increase the dose to 20-40 mg, 2 times a day.

     Possible side effects : gastrointestinal disorders, dizziness, skin rashes, giperkaltsiemiya, thrombocytopenia. Could celebrated moderate metrorragiya; In this case, reduce the dose. It says brain development. In high doses, can show changes in retinal eye.

     The drug is contraindicated in pregnancy.

     Product : pills to 0.01 g (10 mg); 0.02 g (20 mg); 0.04 g (40 mg).

     Storage : in the dark place at room temperature.

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