TIETILPERAZIN (Thiethylperazinum) *. Etiltio-10- 2-[3-(1-metilpiperazinil-4) - propyl] - fenotiazina dimaleat.

     Synonyms : Torekan, Thiethylperazini maleas, Thiethylperazine maleate, Torecan, Toresten, Tresten.

     Tietilperazin to derivative fenotiazina and chemical structure is very close to neyrolepticheskomu drug meterazinu (see). From last tietilperazin is that the nuclei of two fenotiazinovogo hydrogen atom replaced instead Cl S Group C 2 H 5.

     From typical fenotiazinovyh Neuroleptics tietilperazin is that there has expressed sedate activity only slightly potentsiruet of sleeping pills and analgeticheskih substances has not expressed kataleptogennogo action and clinical application is usually strong extrapiramidale violations. However tietilperazin protivorvotnoe have a strong effect; This figure is significantly more active than aminazin and beyond meterazin.

     The drug is effective in vomiting different origins. In the experiment, it suppresses vomiting caused by the excitation point vomitoxin (apomorfinom) and irritation receptors gastrointestinal tract (copper sulfate). Mechanism of protivorvotnogo tietilperazina has a calming effect on the emetic Center and the simultaneous action on hemoretseptornuyu launcher (Trigger) zone suffering brain, while the mechanism of protivorvotnogo aminazina and other drugs fenotiazinovyh hemoretseptornuyu dominant influence on the trigger zone. Tietilperazin is therefore more universal antiemetics funds.

     Tietilperazin applied for the prevention and cessation of nausea and vomiting of different origins, including radiation therapy and chemotherapy in malignant neoplasms, with operational intervention, gastrointestinal diseases, sea and air sickness, migraines, vomiting pregnant. Positive results (ending nausea and vomiting, reduce or end dizziness, eye, walking violations) is coordinating with the vestibular and violations associated with disorders of cerebral circulation, vegetososudistoy dystonia, a disease Menera.

     Assign tietilperazin inside one of Bean (6, 5 mg), 1 to 3 times a day or to impose one candle (6, 5 mg) two times a day (morning and evening), in severe cases, intramuscularly for 1 to 2 ml ( 6 5-13 mg) a day. The course of treatment is continuing with the necessary 2 - 4 weeks. To prevent postoperative vomiting impose intramuscularly 1 ml (6, 5 mg) for about half an hour before the end of the operation.

     The drug is usually well. Sometimes there are dry mouth, drowsiness, posturalnaya hypotension (in high doses). In rare cases (more children) can develop extrapiramidale disorders; In connection with this drug is not recommended to appoint children below the age of 15 years.

     The drug is contraindicated in acute CNS oppression, in a coma.

     Method of issuance : Bean (6, 5 mg); Candles (6, 5 mg); In ampoules of 1 ml (6, 5 mg).

     Storage : List B. In the dark spot.

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