TIOGUANIN (Thioguaninum). Amino-6- 2-mercaptopurine.

     Synonyms : Lanvis, Lanvis, NSC - 752, Thioguanine.

     Yellow or greenish-yellow crystalline powder. Almost nerastvorim in water and alcohol.

     On the chemical structure and mechanism of antitumor action close to mercaptopurine, which differs only in the presence of amino 2.

     As mercaptopurine is antimetabolitom purinov.

     The drug slowly and incompletely absorbed from the gastrointestinal tract. Peak concentrations in plasma observed after 6 to 8 h after administration. About 40% is allocated to the urine within 24 hours (mostly in the form of 5-methylated metabolite).

     Applied primarily with combination therapy of acute and chronic leukaemia. A particularly effective in combination with tsitarabinom (see), and prednisolone, with acute and chronic mieloleykozah (in predblastnoy stage and blastnom Stroke). It can be used in combination with antibiotic therapy.

     Taking into daily for 2 to 3 mg / kg (maximum daily dose of 3 mg / kg). Duration of treatment from 5 to 30 days, depending on the application, effectiveness, portability. When combination therapy (with tsitarabinom, antibiotics) daily intake of 2 - 2, 5 mg / kg; Treatment five days.

     In applying the same tioguanina possible side effects, as in the appointment of mercaptopurine. At the reception tioguanina and after treatment (within 2 weeks), you should at least one time in two weeks to monitor the performance of peripheral blood and blood kostnomozgovogo. At least one per week exploring the function of liver.

     Indications are the same as for mercaptopurine.

     Product : pills to 0.04 g (40 mg) in the banks of dark glasses on 50 pieces or in the film Sitzesteel.

     Storage : List A. In the dark spot.

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