TOBRAMITSIN (Tobramycinum).

     G Amino-3- dezoksi- a -D- glyukozopiranozil- (1-> 6) - O-[2, 6-diamino-2, 3, 6 tridezoksi- a -D- geksopiranozil- Riboflavin (I > 4)] -2 - dezoksi-D- streptamin.

     Synonyms: Brulamitsin, Nebtsin, Obratsin, Brulamycin, Distobram, Gernebcin, Nebcin, Obracin, Tobradistin, Tobrasix and e p.

     Antibiotic group aminoglikozidov, produtsiruemy Str. tenebrarius. Issued in the form of sulphate.

     Like other antibiotikam- aminoglikozidam with broad antibacterial action is active against gram and gram microorganisms. As of antibacterial activity against strains. Ps.aeruginosa is one of the most active in a number aminoglikozidov.

     In vnutrimyshechnom a rapidly absorbed. The maximum concentration in serum found in 30-40 minutes after the introduction. One or intravenous vnutrimyshechnoe introduction provides therapeutic concentrations in the body through 6 to 8 h. Provided mainly kidneys, and urine in a high concentration of the drug.

     Apply tobramitsina sulfate with sepsis, pneumonia, meningitis media, empieme, chest, a urinary tract infection, postoperative nagnoeniyah and other infections caused by susceptible strains of the antibiotic agents.

     Enter usually 2 to 5 mg / kg in the 2 - 3 - 4 admission intramuscularly or intravenously. The maximum daily intake for adults 5 mg / kg (3 to 4 admission), for children 2 to 5 mg / kg (2 to 4 admission). The course of treatment 7 to 10 days.

     If any vydelitelnoy dose reduced kidney function. According to the testimony of emergency imposed in conventional drug doses, but carefully monitor kidney function and the hearing (given nefro-and ototoksichnost drug).

     In patients with vein impose a heavy infection.

     For vnutrimyshechnogo a drug dissolve in 2 to 5 ml of sterile water for injection, intravenous-50-100 ml isotonic sodium chloride solution, or 5% glucose solution (to enter kapelno for 20-60 min).

     Tobramitsin contraindications to the high degree of sensitivity to antibiotikam- aminoglikozidam. The product has a lesser nefro- and ototoksichnostyu than gentamicin and other aminoglycosides, but must take into account the possibility of toxic action. Do not appoint tobramitsin simultaneously with streptomycin, other antibiotikami- aminoglikozidami, tsefaloridinom and strong diuretikami. Tobramitsin not appointed in the first half of pregnancy (see also Kanamitsin).

     Form release: in vials of 40; 50; 75 and 80 mg.

     Storage: sheltered from the world in place with a temperature of + 4 C.

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