TOKOFEROLA acetate (Tocopheroli acetas). Atsetoksi-2- methyl-6 (4, 8, 12 tridetsil trimethylsilyl) - hroman.

     Synonyms : Vitamin E acetate, a Tokoferola acetate Almefrol, Egevit, Esol, Evitaminum, Evitan, Fertiligen, Gonavil, Phytoferol, Profecundin, Tocofyn, a-Tocopherol, Tocovit, Vitaplex E et al.

     Light yellow transparent viscous oily liquid with low odor. In light oxidized and night.

     Tokoferola acetate is a synthetic preparation of vitamin E. The so-called "Vitamin E" is a series of compounds (tocopherol), close to the chemical nature and the biological effects. Chief among them is a-tokoferol.

     Tokoferoly contained in the green parts of plants, especially in young growing grains; Tokoferolami rich in vegetable oils (sunflower, cotton, corn, peanut, soybean, sea). A number of them are also found in meat, fat, eggs, milk.

     Vitamin E is the natural resistance of (antioxidant). It protects the different substances from oxidizing change. Participates in the Hema and protein biosynthesis, cell proliferation in tissue breath and other critical processes of cell metabolism.

     The important role played by vitamin E in the body. For animals, deprived of vitamin E, found degenerative changes in skeletal muscle and heart muscle, have increased permeability and capillary wall, turned epithelial seed Channel, eggs. There embryos are bleeding, it's their intrauterine death. There are also changes in the degenerative nerve cells and defeat parenhimy liver. A shortage of vitamin E may be linked Hemolytic jaundice in newborns, steatoreya, malabsorbtsii syndrome, etc.

     Recently, the attention attracted antioxidant properties tokoferola (See Antigipoksanty and antioxidants.) .

     Antioxidant properties are also drugs BHT (see), emoksipin (see), and several other drugs. These funds hindered the peroxide oxidation of lipids (POL). Because of that, in several pathological processes are activated, and the accumulation of lipid oxidation products POL in organs and tissues (including blood plasma), antioxidants have been used in the treatment of various diseases. Of particular use was tokoferola acetate.

     Basically tokoferola acetate used as a drug with muscular dystrophy, dermatomiozitah, amotroficheskom lateral sclerosis, menstrual irregularities, threatened abortion, sexual violation as iron men. There are performance tokoferola with some Medicine, doctor, peripheral vascular spasm.

     In paediatric practice tokoferol effective in sclerodermia, malnutrition and other diseases.

     In connection with antiaksidantnymi properties tokoferola acetate found use in treatment of cardiovascular disease, eye disease, to reduce the adverse effect in the treatment of chemotherapy drugs, etc.

     There is evidence that tokoferol can improve convulsants of epilepsy in patients who have found elevated blood products peroxide oxidation of lipids.

     Assign tokoferola acetate inside and intramuscularly.

     To be accepted into publishing solution tokoferola acetate in oil (Solutio Toso pheroli emplacement tatis oleosa) 5%, 10% and 30%. In 1 ml containing 50; 100, and 300 mg of synthetic a-tokoferola acetate.

     Assign drug inside in the following doses : neuro-muscular diseases system (with muscular dystrophy, amiotroficheskom lateral sclerosis, etc.) 50-100 mg / day, for 1 to 2 months, refresher courses are designated by 2 to 3 months; Men in violation spermatogeneza and potency - 100-300 mg / day (in combination with hormonal therapy) for a period of 1 month; abortion in the intimidating 100-150 mg per day for 7 to 14 days, while preserving abortion and the deterioration of foetal development - 100-150 mg / day in the first 2 to 3 months of pregnancy every day or two; peripheral vascular disease, myocardiodystrophy, atherosclerosis, 100 mg / day (with vitamin A; see Aevit) for a period of 20 to 40 days, after 3 to 6 months of treatment with vitamin E can be repeated.

     When skin diseases appoint 50-100 mg / day for 20 to 40 days.

     In the treatment of cardiovascular, eye and other diseases are on the inside 0.05; 0.1 g 1 to 2 times daily rates for 1 - 2 - 3 weeks.

     Breast children in sclerodermia, malnutrition and low resistance capillaries appoint 5 to 10 mg per day.

     For intramuscular injections produced acetate solution tokoferola in oil 5%, 10%, 30% (Solutio Tosor heroli emplacement tatis on l e osa 5%, 10%, 30% on injectionibus p r).

     Injections usually produce violations intake of vitamin E and sharing in the body.

     Doses are the same as when ingestion. Enter in the form of hot every day or two.

     For intramuscular injections may pain, the emergence of infiltrates and allergic reactions.

     There is a need to be cautious about the use of drugs vitamin E in patients with severe cardiosclerosis and heart attacks.

     Product : reception inside the 5%, 10% and 30% solutions in orange glass bottles to 10; 20; 25 and 50 ml and capsules, containing 0.1 or 0.2 ml of 50% solution (0.05 or 0.1 g tokoferola acetate). One drop of 5%, 10% or 30% solution of Ophthalmic drug pipettes contains about 1; 2 or 6, 5 mg a-tokoferola acetate; Injection drug available in capsules of 1 ml 5%; 10% or 30% solution ( accordingly, 50; 100 or 300 mg).

     Drugs vitamin E remain well ukuporennoy dishes in the dark spot. Ultraviolet rays destroy vitamin E.

     Tokoferola acetate is a member of the combined (multivitamin) drugs (see Aevit, Aekol, Undevit, Aerovit, Gendevit, Glutamevit).

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