TOLKAPON (tolcapone).

     3,4 - Digidroksi-4'- metil-5- nitrobenzofenon.

     Synonym : Tasmar, Tasmar.

     As katehol-0- metiltransferazy inhibitor, suppresses biotransformation levodopa.

     When used in combination with the drug levodopa increases their efficiency and reduces side effects.

     Rapidly absorbed in the digestive tract, bioavailability of 65-90%, max S-2 h, T1 / 2 to 2 hours; Kidney presented mostly in the form of metabolites.

     Applied with Parkinson's disease (in combination with the drug levodopa forms).

     Assign inside of 0,1-0,2 g three times a day.

     Possible side effects : insomnia, psoriasis, neuralgia.

     After a sharp lifting of drug development syndromic probably akin to neuroleptic malignant syndrome.

     The drug is contraindicated in pregnancy and breastfeeding; No appointment with MAO inhibitors.

     To designate a patient with caution expressed Disabilities liver and kidney (every six weeks therapy to determine levels transaminaz).

     Product : pills for 0.1 and 0.2 g (N. 10, 30, 60, 100).

     Storage : List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines