TOLPERIZON (Tolperisone)

     Chemical name : Methyl 2 - (4-methylphenyl) -3 - (1-piperidinil) -1 - propanone (as hydrochloride)

     Pharmacology : The drugs act-miorelaksiruyuschee, vazodilatiruyuschee.

Central Lock-n-holinoretseptory (including in kaudalnyh divisional structures formation), polisinapticheskie spinal reflexes. When administered in a thin skin ulcers. Cmax plasma determined by 0,5-1 hours Pronounced "first pass effect" through the liver, resulting in low bioavailability (approximately 18%). Metabolised in the liver. T1 / 2 when administered 1,5-hour, with v / a-2.5 hours Muscle Spasticity proved significant weakening.

     Application : Condition, accompanied gipertonusom skeletal muscles in the face of defeat organic neurological (damage to the pyramid, multiple sclerosis, mielopatiya, thought, muscle spasm, muscle gipertonus, muscle contracture, spinal automatic), extrapiramidale disorder (postentsefalichesky and aterosklerotichesky parkinsonizm), epilepsy, encephalopathy vascular genesis, obliteriruyuschie disease (atherosclerosis vascular obliteriruyuschy limbs, obliteriruyuschy endarteriit, sclerodermia system, obliteriruyuschy trombangiit, diabetic angiopatiya, Reino syndrome), including against the backdrop of vascular innervation, posttromboticheskie violations blood and lymphatic; in pediatrics disease Littlya (child spastic paralysis).

     Contraindications : Giperchuvstvitelnost (including to the lidocaine), male heavy currents.

     Restrictions on the use : Pregnancy, breast-feeding, early childhood (up to 3 years).

     Application of pregnancy and breastfeeding : Protivopokazano pregnancy. At the time of treatment should stop breastfeeding.

     Side Effects : Dispepsiya (nausea, vomiting, abdominal discomfort), drowsiness, reduced muscle strength, arterial hypotension, allergic reactions (anaphylactic shock, bronchospasm, urticaria, erythema, skin itch).

     Networking : The effect of increased funding for narcosis, peripheral muscle, distribution network, Clonidine.

     Overdosing : Symptoms : respiratory depression (from paresis diaphragm and direct braking respiratory centre) and the heart, arterial hypotension.

Treatment : symptoms.

     Dosing and Administration : Adults, inside-50-150 mg three times daily. / M-1 ml (100 mg) two times a day. In / in 1 ml / day (100 mg) once. Children from 3 months to 6 years, inside the 5 mg / kg / day for 3 admission. Children 7-14 years, inside-2-4 mg / kg / day in 3 installments.

Materials allowed to copy only with the active hyperlink to the handbook of medicines