URAPIDIL (Urapidil) *. 6-[[3-[4 - (ortho Metoksifenil) -1 - piperazinil] propyl] - amino] -1, 3 dimetiluratsil.

     Issued as hydrochloride.

     Synonyms: Ebrantil, Ebrantil, Eupressyl.

     According to the structure of the side chain has some similarities with tsinnarizinom.

     Provides hypotensive effect; Reduces peripheral vascular resistance. The effect partly due to a decrease in the flow of central sympathetic sosudosuzhivayuschih counters, in part, a peripheral 1-adrenoblokiruyuschim action. The mechanism is not fully understood.

     The main drug used to reduce the AD with PNDS crises (see also Klofelin), as well as in the form of ongoing severe hypertension, including in cases resistant to the actions of other antigipertenzivnyh funds.

     Assign intravenously and inside.

     In acute and severe form of ongoing hypertension impose intravenous dose in adults is usually 0,025 g (25 mg), ie 1 vials (5 ml) 0.5% solution (within 5 minutes). With little effect enter after 2 minutes the same dose, and with the lack of effect of the dose over two minutes through a slow intravenous 50 mg. In reaching effect after the first, second or third shift at a slow drip infusions. For acute 250 mg urapidila razvodyat in 500 ml isotonic sodium chloride solution, or 5 - 10% glucose solution. Enter by applying pump at a rate of 9 to 30 mg per hour (average 15 mg / h).

     The duration depends on the severity of disease, receive benefits and portability (of not more than 7 days). After receiving the necessary effect can switch to receive the drug inside.

     For long-term therapy antigipertenzivnoy appoint urapidil inside capsules. Usually beginning with 30 mg 2 times a day or 60 mg 2 times a day, selecting dose individually. Daily dose may vary from 30 to 180 mg. Take the morning and evening during the meal; Capsules proglatyvayut not razzhevyvaya, ?high little liquid.

     When you receive inside urapidil generally well tolerated by, but may dizziness, headache, general weakness, heart, gastrointestinal disorders, drought in the mouth; Moreover, the phenomenon ortostatichesksogo collapse. Sometimes there allergic skin reactions, thrombocytopenia.

     With the rapid introduction of intravenous can develop kollaptoidnoe state.

     The product contraindications in pregnancy. He did not designate children. Treatment of patients older beginning with the appointment of smaller doses. Other Antihypertensive drugs can increase the effect urapidila. Not recommended (in the absence of sufficient experience) apply urapidil while adenozinkonvertiruyuschego enzyme inhibitors (see Kaptopril).

     Do not appoint urapidil (for outpatient care) transport drivers and those of other professions that require rapid physical and mental reactions.

     Do not confuse urapidila solution with alkaline liquid phase (perhaps fallout sludge).

     Method of issuance: capsules (slow, retardirovannogo action) to 30; 60, and 90 mg in the package and 20; 50 and 100 pieces; 0.5% intravenous solution in the ampoule of 5 and 10 ml (25 and 50 mg) in the package of 10 vials.

     Storage: List B.

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