VANKOMITSIN (Vancomycin).

     Synonyms : Vankoled, Vankotsin, Vanmiksan, Editsin, Edicin, Vancocin, Vancoled, Vanmixan.

     Powder. Well soluble in water, moderate-to methanol.

     Tricyclic glikopeptidny antibiotic produtsiruemy Amycolatopsis orientalis.

     Active in a number of micro gram (staphylococcus, streptococcal pneumococcal, enterokokkov, korinebaktery, listery, aktinomitsetov and klostridy).

     Forming a set of acyl-D alanin- Dr. alaninom mukoproteina cell walls of bacteria, violating its formation, and membrane permeability tsitoplazmaticheskoy RNA synthesis, leading to lysis of bacteria.

     If ingestion is not absorbed; After injecting therapeutic concentrations in the blood are maintained 8-10 h, T? at 1-8 h, quickly enters the pleura cavity and attacks, virus and astsiticheskuyu liquid; displayed mostly kidneys unchanged.

     Applied in the most severe infectious inflammatory diseases, due mostly golden (metitsillinorezistentnym) and koagulazootritsatelnymi staphylococcus, and pneumococcal enterokokkami, insensitive penitsillinam, deposits and other antibiotics : sepsis, endocarditis, pneumonia, abscess light, bullet, meningitis, peritonitis, skin infection , psevdomembranoznom Colitis (inside and inefficiency metronidazole); to prevent postoperative infections (mainly in the cardiovascular surgery and orthopedics), as well as (inside) with acute and chronic liver diseases (including liver encephalopathy).

     Assign intravenously and inside.

     Intravenous drip type (for a period of not less than 1 hour) for adults 2 g (200 ml of 5% glucose solution and isotonic solution of sodium chloride) per day in 2-4 reception (in surgical practice, 1 g for 1 h before the operation) children 40-60 mg / kg (up to 2 grams) a day in four installments.

     Inside (a solution) if psevdomembranoznom Colitis designate an adult to 0,5-2 grams a day, children 40 mg / kg / day (3-4 admission); When liver encephalopathy-in 1-2 g 3 times a day within 5-7 days.

     Possible side effects : diarrhoeal phenomenon, allergic reactions, rarely thinking and nefrotoksicheskoe effect; After intravenous-throm, vaskulit, fever, neutropenia, thrombocytopenia, with the rapid introduction (intravenous) - arterial hypotension, burning feeling, Blush top of the body , the pain and muscle cramps in her back and chest.

     Contraindications : audible optic nerve, kidney failure, I trimester of pregnancy.

     Product : dried powders in vials of 0.5 and 1 year

     Storage : List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines