VINBLASTIN (Vinblastinum).

     Alkaloid contained in the plant Madagascar pink (Vinca rosea L.), as well as a plant katarantus (Catharanthus roseus L.).

     Available in the form of sulphate.

     Refers to a number of indole alkaloids.

     Synonyms : Velbe, Tsitoblastin, Blastovin, Cytoblastine, Exal, Periblastine, Velban, Velbe, Vinblastine, Vincaleukoblastine.

     Patriotic called Rozevin (Rosevinum).

     White or white with cream flavor melkokristallichesky powder. Gigroskopichen, sensitive to light. The easily soluble in water, virtually nerastvorim of alcohol.

     Vinblastine is cytotoxic substances with antitumor activity.

     The mechanism of anticancer drugs to block explain the ability of cells to Mitosis metafazy stage.

     Vinblastine is depressingly at leykopoez and trombotsitopoez; No major impact on Erythropoiesis.

     Applied vipblastin (rozevin) with chlamydia, gematosarkomah, mielomnoy disease horiokartsinome.

     Enter drug intravenously once a week. Before use, the contents of a bottle of initiation (5 mg) in 5 ml isotonic sodium chloride solution. Initial dose of 0,025 mg / kg, and then gradually increase the dose (to the number of cells and platelets in the blood) to 0.15 - 0.3 mg / kg. Heading dose of 100-120 mg. Absent the effect of a drug drop in the total dose of 50 mg. If a therapeutic effect, a long-term supportive therapy, selecting dose, which is in regular use does not diminish the level of red blood below 3 x 10 9 / L. Diluted introduce one every 2 to 4 weeks. In the case of deterioration of the patient reduce the interval between the introduction.

     Vinblastine (rozevin) is widely used in integrated cancer chemotherapy in combination therapy with other drugs.

     In applying the product may general weakness, loss of appetite, nausea, vomiting, abdominal pain, parestezii, hypertensive, jaundice, stomatitis, urticaria, depression, Alopecia, flebity.

     Treatment of systematic control of a picture of blood; Tests conducted one every three days. With a decrease in leukocyte count to 3 x 10 9 / L, and platelets 100 x 10 9 / L stop drug use. If necessary, designate a blood transfusion or her uniform elements antibiotics.

     The drug is not suitable for oppression haematopoietic system, diarrhoeal diseases and gastric ulcers and duodenal ulcers, in the terminal phase of illness.

     It should guard against falling solutions under the skin because of severe tissue.

     Product : The dried form (porous mass of white or white with a slightly yellowish sheen color) in ampoules and vials of 0,005 grams (5 mg).

     Storage : List A. In the dark place at a temperature no higher than + 10 C.

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