VINKRISTIN (Vincristine).

     Alkaloid contained in the plant Madagascar pink (Vinca rosea L.).

     By building close to vinblastinu (see).

     Synonyms : Leurocristine, Oncovin, Vincristine sulfate, Vincrisul.

     Has cytostatic activity on the mechanism of close to vinblastinu.

     Applied mainly in the treatment of acute leukemia, neyroblastomy, Vilmsa tumors; Also used in the treatment of infection, melanoma, breast cancer and other tumors.

     Enter vincristine 1 intravenously once a week : 1-week 0.05 mg / kg in the 2 nd - 0,075 mg / kg, in the third-0.1 mg / kg, 4 th-0 , 125 mg / kg and then 0.15 mg / kg. On reaching remission appoint 0.05 - 0,075 mg / kg 1 week (supporting dose).

     When using vincristine possible radiation. The drug can cause neurotoxic effects and parestezii, motor disorders, central nervous system damage focal possible paresis intestines, sometimes with a picture of paralytic intussusception. There also Alopecia, ulcerative stomatitis, choke pain ataxy, weight loss, nausea, vomiting, increased body temperature, poliuriya. In the process of treatment should be carefully monitor the patient for blood tests.

     In the case of a severe hemorrhagic such events as the application rozevina. Application vincristine be discontinued if developed peripheral neuritis, severe constipation, greatly increasing body temperature.

     Product : in vials containing 0.5 mg dried vincristine sulfate, adding solvent to 10 ml ampoules.

     Storage : List A. In a cool place.

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